Homo sapiens keratin 8 (KRT8), transcript variant 2
Synonyms:
CARD2; CK-8; CK8; CYK8; K2C8; K8; KO
Immunogen
A phospho specific peptide corresponding to residues surrounding serine 23 of human CK-8 was used as an immunogen. This antibody detects CK-8 phosphorylated on serine 23.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Keratin polypeptides 8 and 18 (K8/18) are intermediate filament phosphoglycoproteins that are expressed preferentially in glandular epithelia. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells (1-3). Together with actin microfilaments and microtubules, keratin filaments make up the cytoskeletons of vertebrate epithelial cells, forming alpha-helical coiled-coil dimers which associate laterally and end-to-end to form 10-nm diameter filaments (4).
Related Pathway
EGFR1 Signaling Pathway
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Western blot analysis on HeLa cell lysates using anti-Phospho-CK-8 (pS23), 1:50,000 dilution. Cells were either (A) untreated (B) treated with Calyculin
