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Home Antibody All anti-CRK antibodies

Anti-CRK PHOSPHO Antibody EPR269Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301012
  • Rabbit Monoclonal Antibody against CRK (Clone EPR269Y) (Phospho-specific)
100ul 325 In Stock
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WB(1)
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Also for CRK (NM_005206)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to regions surrounding Tyrosine 221 was used as an immunogen. This antibody detects proteins phosphorylated at Y221.
Clone NameEPR269Y IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:2000; ICC: 1:50 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens v-crk avian sarcoma virus CT10 oncogene homolog (CRK), transcript variant I
Alternative NameCRKII; p38
Database LinkNP_005197
Entrez Gene 1398 Human
FunctionCrk (p38) are adaptor proteins, composed mostly of SH2 and SH3 domains, which play a key role in cellular signaling by mediating the construction of protein complexes and also by managing cell proliferation, differentiation, and migration (1). They are critical integrators of upstream signals for cell invasion and migration in human cancer cell lines. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been observed in multiple human cancers (2). In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth (3). Crk associates with ERM family proteins (including ezrin, radixin, and moesin), activates RhoA, and promotes cell motility toward hyaluronic acid (4).
Related PathwayTranscription FactorsDruggable Genome MAPK signaling pathwayErbB signaling pathwayChemokine signaling pathwayFocal adhesionFc gamma R-mediated phagocytosisNeurotrophin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Crk p38 (phospho Y221) antibody [EPR269Y]; All lanes : Anti-Crk p38 (phospho Y221) antibody [EPR269Y] at 1/2000 dilution.Lane 1 : K562 cell lysate.Lane 2 : K562 cell lysate treated with AP.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 34 kDa.Observed band size : 34 kDa.

 

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