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Home Antibody All anti-STK4 antibodies

Anti-STK4 PHOSPHO Antibody EPR1467Y

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SKU Description Amount Price Availability*  
TA300998 Rabbit Monoclonal Antibody against STK4 (Clone EPR1467Y) (Phospho-specific) 100ul $325 In Stock
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WB(1)

OriGene Data

ImmunogenA phospho synthetic peptide corresponding to residues surrounding Threonine 183 of human Mst1 or Threonine 180 of human Mst2.
Clone NameEPR1467Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:2000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens serine/threonine kinase 4 (STK4)
Alternative NameKRS2; MST1; TIIAC; YSK3
Database LinkNP_006273
Entrez Gene 6789 Human
FunctionThe human serine/threonine kinase, mammalian STE20-like kinase (MST), is considerably homologous to the budding yeast kinases, SPS1 and STE20, throughout their kinase domains. When stably expressed in HeLa cells, MST highly sensitizes the cells to death receptor-mediated apoptosis by accelerating caspase-3 activation. These findings suggest that MST1 and MST2 play a role in apoptosis both upstream and downstream of caspase activation (1). MST1 is cleaved and activated by caspases during apoptosis and is capable of inducing apoptotic morphological changes such as chromatin condensation upon overexpression (2). Mammalian Sterile 20-Like 2 (Mst2) is most similar to the previously identified Mst1 protein kinase (78% identity, 88% similarity). Northern analysis indicates that MST2 mRNA is expressed at high levels in adult kidney, skeletal and placental tissues and at very low levels in adult heart, lung, liver and brain tissues. An in-vitro kinase assay indicates that Mst2 can phosphorylate an exogenous substrate, as well as itself, and phospho-amino-acid analysis indicates that it is a serine/threonine protein kinase (3)
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayPathways in cancerNon-small cell lung cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - MST1/MST2 (phospho T183 + T180) antibody [EPR1467Y]; All lanes : Anti-MST1/MST2 (phospho T183 + T180) antibody [EPR1467Y] at 1/2000 dilution.Lane 1 : HeLa cell lysate, untreated.Lane 2 : HeLa cell lysate treated with Calyculin A.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/1000 dilution.Predicted band size : 56 kDa.Observed band size : 59 kDa .
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