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Anti-STK4 PHOSPHO Antibody EPR1467Y
Also for STK4 (NM_006282)
|A phospho synthetic peptide corresponding to residues surrounding Threonine 183 of human Mst1 or Threonine 180 of human Mst2.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:2000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens serine/threonine kinase 4 (STK4)|
|KRS2; MST1; TIIAC; YSK3|
Entrez Gene 6789 Human
|The human serine/threonine kinase, mammalian STE20-like kinase (MST), is considerably homologous to the budding yeast kinases, SPS1 and STE20, throughout their kinase domains. When stably expressed in HeLa cells, MST highly sensitizes the cells to death receptor-mediated apoptosis by accelerating caspase-3 activation. These findings suggest that MST1 and MST2 play a role in apoptosis both upstream and downstream of caspase activation (1). MST1 is cleaved and activated by caspases during apoptosis and is capable of inducing apoptotic morphological changes such as chromatin condensation upon overexpression (2). Mammalian Sterile 20-Like 2 (Mst2) is most similar to the previously identified Mst1 protein kinase (78% identity, 88% similarity). Northern analysis indicates that MST2 mRNA is expressed at high levels in adult kidney, skeletal and placental tissues and at very low levels in adult heart, lung, liver and brain tissues. An in-vitro kinase assay indicates that Mst2 can phosphorylate an exogenous substrate, as well as itself, and phospho-amino-acid analysis indicates that it is a serine/threonine protein kinase (3) |
|Protein KinaseDruggable Genome MAPK signaling pathwayPathways in cancerNon-small cell lung cancer|
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Western blot - MST1/MST2 (phospho T183 + T180) antibody [EPR1467Y]; All lanes : Anti-MST1/MST2 (phospho T183 + T180) antibody [EPR1467Y] at 1/2000 dilution.Lane 1 : HeLa cell lysate, untreated.Lane 2 : HeLa cell lysate treated with Calyculin A.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/1000 dilution.Predicted band size : 56 kDa.Observed band size : 59 kDa .