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Home Antibody All anti-ENDOG antibodies

Anti-ENDOG Antibody EP1665Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300992
  • Rabbit Monoclonal Antibody against ENDOG (Clone EP1665Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417987) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human Endo G was used as an immunogen.
Clone NameEP1665Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:2000 - 1:5000
Predicted MW Explanation 36 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens endonuclease G (ENDOG)
Alternative NameFLJ27463
Database LinkNP_004426
Entrez Gene 2021 Human
Entrez Gene 13804 Mouse
Entrez Gene 362100 Rat
FunctionEndonuclease G (endoG) is a mitochondrion-specific nuclease that translocates to the nucleus during apoptosis. Once released from mitochondria, endoG cleaves chromatin DNA into nucleosomal fragments independently of caspases. Therefore, endoG represents a caspase-independent apoptotic pathway initiated from the mitochondria (1). Endonuclease G (EndoG) is a nuclear-encoded mitochondrial protein reported to be important for both nuclear DNA fragmentation during apoptosis and mitochondrial DNA replication. Findings indicate that EndoG is essential during early embryogenesis and plays a critical role in normal apoptosis and nuclear DNA fragmentation (2).
Related PathwayDruggable Genome Apoptosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Endo G antibody [EP1665Y] - Carboxyterminal end; Anti-Endo G antibody [EP1665Y] - Carboxyterminal end at 1/2000 dilution + HepG2 cell lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/1000 dilution.developed using the ECL technique.Predicted band size : 36 kDa.Observed band size : 35 kDa .

 

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