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Anti-ENDOG Antibody EP1665Y
Also for ENDOG (NM_004435)
|A synthetic peptide corresponding to residues on the C-terminus of human Endo G was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:2000 - 1:5000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens endonuclease G (ENDOG)|
Entrez Gene 2021 Human
Entrez Gene 13804 Mouse
Entrez Gene 362100 Rat
|Endonuclease G (endoG) is a mitochondrion-specific nuclease that translocates to the nucleus during apoptosis. Once released from mitochondria, endoG cleaves chromatin DNA into nucleosomal fragments independently of caspases. Therefore, endoG represents a caspase-independent apoptotic pathway initiated from the mitochondria (1). Endonuclease G (EndoG) is a nuclear-encoded mitochondrial protein reported to be important for both nuclear DNA fragmentation during apoptosis and mitochondrial DNA replication. Findings indicate that EndoG is essential during early embryogenesis and plays a critical role in normal apoptosis and nuclear DNA fragmentation (2). |
|Druggable Genome Apoptosis|
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Western blot - Endo G antibody [EP1665Y] - Carboxyterminal end; Anti-Endo G antibody [EP1665Y] - Carboxyterminal end at 1/2000 dilution + HepG2 cell lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/1000 dilution.developed using the ECL technique.Predicted band size : 36 kDa.Observed band size : 35 kDa .