The retinoic acid receptors (RARs) are family of nuclear receptors that mediates effects of retinoic acid (RA, acidified form of vitamin A), a non-steroid hormone involved in cell proliferation, differentiation, and apoptosis (1). Three isoforms of RAR exists (RAR alpha, beta, and gamma) and forms a heterodimer with RXRs (retinoid X receptor, a distant related receptor). When bound to RA, RARs acts as transcription factors and binds to thyroid hormone response element or RA response element (RARE), activating gene expression (2). RAR alpha has been implicated as important biomedical marker in the pathogenesis of acute promyelocytic leukemia (APL) (3).
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