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Home Antibody All anti-ERBB2 antibodies

Anti-ERBB2 Antibody EP1045Y

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA300959 Rabbit Monoclonal Antibody against ERBB2 (Clone EP1045Y) 100uL $325 In Stock
LC417979 ERBB2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
IF(1)
Assay(1)
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Also for ERBB2 (NM_004448)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human Her2 was used as an immunogen. This antibody detects Her2 phosphorylated at Tyr1248 as well as unphosphorlyated Her2.
Clone NameEP1045Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, Assay, IHC, IF Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:50; FC: 1:30; ICC/IF: 1:250 - 1:500; IHC-P: 1:100 - 1:250
Predicted MW Explanation 137 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript variant 1
Alternative NameCD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Database LinkNP_004439
Entrez Gene 2064 Human
FunctionErbB2/HER2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.
Related PathwayProtein KinaseTransmembraneDruggable Genome ErbB signaling pathwayCalcium signaling pathwayFocal adhesionAdherens junctionPathways in cancerPancreatic cancerMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-ErbB 2 antibody [EP1045Y]; Anti-ErbB 2 antibody [EP1045Y] at 1/10000 dilution + SKBR-3 cell lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 137 kDa.
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Other-Anti-ErbB 2 antibody [EP1045Y](TA300959); Equilibrium disassociation constant (KD)..
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ErbB 2 antibody [EP1045Y]; Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue labelling ErbB 2 with TA300959 at 1/100 dilution.
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Immunocytochemistry/ Immunofluorescence - Anti-ErbB 2 antibody [EP1045Y]; Immunofluorescent analysis of SKBR cells labelling ErbB 2 with TA300959 at 1/250 dilution.
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