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Home Antibody All anti-ERBB2 antibodies

Anti-ERBB2 Antibody EP1045Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300959
  • Rabbit Monoclonal Antibody against ERBB2 (Clone EP1045Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417979) , 20ug
100uL 325 In Stock
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WB(1)
IHC(1)
IF(1)
Assay(1)
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Also for ERBB2 (NM_004448)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human Her2 was used as an immunogen. This antibody detects Her2 phosphorylated at Tyr1248 as well as unphosphorlyated Her2.
Clone NameEP1045Y IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC, IF Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:50; FC: 1:30; ICC/IF: 1:250 - 1:500; IHC-P: 1:100 - 1:250
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 1
Alternative NameCD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Database LinkNP_004439
FunctionErbB2/HER2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.
Related Pathway
Adherens junction
Focal Adhesion

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-ErbB 2 antibody [EP1045Y]; Anti-ErbB 2 antibody [EP1045Y] at 1/10000 dilution + SKBR-3 cell lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 137 kDa.
Assay Image
Other-Anti-ErbB 2 antibody [EP1045Y](TA300959); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ErbB 2 antibody [EP1045Y]; Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue labelling ErbB 2 with TA300959 at 1/100 dilution.
IF Image
Immunocytochemistry/ Immunofluorescence - Anti-ErbB 2 antibody [EP1045Y]; Immunofluorescent analysis of SKBR cells labelling ErbB 2 with TA300959 at 1/250 dilution.

 

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