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Anti-HSF2 Antibody EPR1715Y
Also for HSF2 (NM_004506)
|A synthetic peptide corresponding to residues near the C-terminus of human HSF2 was used as an immunogen|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:500; FC: 1:30; ICC/IF: 1:50
|Does not react with Mouse, Rat. Is unsuitable for IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for IHC-P or IP.
|Homo sapiens heat shock transcription factor 2 (HSF2), transcript variant 1|
|HSF 2; HSTF 2|
|The heat shock response is transcriptionally regulated by an evolutionarily conserved protein termed heat shock factor (HSF). It appears that there is a human heat shock factor gene family and that at least two separate but related HSF proteins regulate the stress response in humans (1). HSF2, one of the heat shock transcription factors in mammalian cells, is localized to the cytoplasm during normal growth and moves to the nucleus upon activation. Heat shock transcription factors in metazoans contain four hydrophobic heptad repeat sequences, three in the amino terminus and one in the carboxy terminus, which are predicted to form alpha-helical coiled-coil structures analogous to the leucine zipper. It is believed that zipper domains can regulate subcellular localization (2). The promoter regions of some genes, such as the stress-inducible hsp70i gene that codes for a heat shock protein, remain uncompacted, a phenomenon called bookmarking. It has been shown that hsp70i bookmarking is mediated by transcription factor HSF2 (3) |
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Western blot - HSF2 antibody [EPR1715Y]; Anti-HSF2 antibody [EPR1715Y] at 1/500 dilution + Hela cell lysate at 10 µg.Secondary.Goat anti-rabbit HRP labeled at 1/2000 dilution.Predicted band size : 60 kDa.Observed band size : 60 kDa.