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Home Antibody All anti-HSF2 antibodies

Anti-HSF2 Antibody EPR1715Y


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA300942 Rabbit Monoclonal Antibody against HSF2 (Clone EPR1715Y) 100ul $325 In Stock
LC401434 HSF2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human HSF2 was used as an immunogen
Clone NameEPR1715Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500; FC: 1:30; ICC/IF: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameHomo sapiens heat shock transcription factor 2 (HSF2), transcript variant 1
Alternative NameHSF 2; HSTF 2
Database LinkNP_004497
Entrez Gene 3298 Human
FunctionThe heat shock response is transcriptionally regulated by an evolutionarily conserved protein termed heat shock factor (HSF). It appears that there is a human heat shock factor gene family and that at least two separate but related HSF proteins regulate the stress response in humans (1). HSF2, one of the heat shock transcription factors in mammalian cells, is localized to the cytoplasm during normal growth and moves to the nucleus upon activation. Heat shock transcription factors in metazoans contain four hydrophobic heptad repeat sequences, three in the amino terminus and one in the carboxy terminus, which are predicted to form alpha-helical coiled-coil structures analogous to the leucine zipper. It is believed that zipper domains can regulate subcellular localization (2). The promoter regions of some genes, such as the stress-inducible hsp70i gene that codes for a heat shock protein, remain uncompacted, a phenomenon called bookmarking. It has been shown that hsp70i bookmarking is mediated by transcription factor HSF2 (3)
Related PathwayTranscription Factors

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - HSF2 antibody [EPR1715Y]; Anti-HSF2 antibody [EPR1715Y] at 1/500 dilution + Hela cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP labeled at 1/2000 dilution.Predicted band size : 60 kDa.Observed band size : 60 kDa.


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