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Anti-MAPK9 Antibody EP1595Y
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Also for MAPK9 (NM_002752)
|A synthetic peptide corresponding to residues near the C-terminus of human JNK2 was used as an immunogen.|
|Human, Mouse, Rat
||WB: 1:2,000~50,000; IHC: 1: 100 250; ICC: 1: 100 250; FC: 1:40; IP: 1: 100
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens mitogen-activated protein kinase 9 (MAPK9), transcript variant JNK2-a2|
|JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a|
|JNK protein kinases are distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group includes the 46-kDa isoform JNK1 and the 55-kDa protein kinase JNK2. The activities of both JNK isoforms are markedly increased by exposure of cells to UV radiation (1). JNK becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase MKK4 and MKK7 (2). JNK2 functions in a cell-type-specific and stimulus-dependent manner, being required for apoptosis of immature thymocytes induced by anti-CD3 antibody but not for apoptosis induced by anti-Fas antibody, UVC or dexamethasone. JNK2 is not required for activation-induced cell death of mature T cells (3). |
MAPK signaling pathway
TGF Beta Signaling Pathway
Toll-like receptor signaling pathway
Wnt Signaling Pathway
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Western blot analysis on HeLa cell lysate using anti-JNK2, dilution 1:50,000.
Immunohistochemical staining of paraffin-embedded human breast carcinoma using anti-JNK2.