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Home Antibody All anti-PPP1CB antibodies

Anti-PPP1CB Antibody EP1804Y


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA300926 Rabbit Monoclonal Antibody against PPP1CB (Clone EP1804Y) 100ul $325 In Stock
LC400955 PPP1CB HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues on human PP1 beta was used as an immunogen.
Clone NameEP1804Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, FC Suggested DilutionsWB: 1:100000 - 1:200000; IP: 1:100; FC: 1:25; IHC-P: Use at an assay dependent dilution
Predicted MW Explanation 37 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC.

Reference Data

Target NameHomo sapiens protein phosphatase 1, catalytic subunit, beta isozyme (PPP1CB), transcript variant 1
Alternative NameHEL-S-80p; PP-1B; PP1B; PP1beta; PPP1CD
Database LinkNP_002700
Entrez Gene 5500 Human
Entrez Gene 19046 Mouse
Entrez Gene 25594 Rat
FunctionProtein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase that regulates an enormous variety of cellular functions through the interaction of its catalytic subunit (PP1c) with over fifty different established or putative regulatory subunits (1). The coordinated and reciprocal action of serine/threonine (Ser/Thr) protein kinases and phosphatases produces transient phosphorylation, a fundamental regulatory mechanism for many biological processes. PP1 is ubiquitously distributed and regulates a broad range of cellular functions, including glycogen metabolism, cell-cycle progression and muscle relaxation. PP1 has evolved effective catalytic machinery but lacks substrate specificity. Substrate specificity is conferred upon PP1 through interactions with a large number of regulatory subunits (2). It has been shown that PP1 determines the efficacy of learning and memory by limiting acquisition and favoring memory decline. When PP1 is genetically inhibited during learning, short intervals between training episodes are sufficient for optimal performance (3).
Related PathwayPhosphataseDruggable Genome Oocyte meiosisVascular smooth muscle contractionFocal adhesionLong-term potentiationRegulation of actin cytoskeletonInsulin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Protein Phosphatase 1 beta antibody [EP1804Y]; Anti-Protein Phosphatase 1 beta antibody [EP1804Y] at 1/200000 dilution + Jurkat cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP labeled at 1/2000 dilution.Predicted band size : 37 kDa.Observed band size : 37 kDa.
Immunohistochemistry (Paraffin-embedded sections) - Protein Phosphatase 1 beta antibody [EP1804Y]; Paraffin embedded human muscle labelled with TA300926 at 1/100 - 1/250 dilution
Flow Cytometry-Anti-Protein Phosphatase 1 beta antibody(TA300926); Overlay histogram showing HeLa cells stained with TA300926 (red line). The secondary antibody used was DyLight 488 goat anti-rabbit IgG (H+L) at 1:500. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1ug/1x10^6 cells) used under the same conditions. Acquisition of >5,000 events was performed.


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