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Home Antibody All anti-MMP14 antibodies

Anti-MMP14 Antibody EP1264Y


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA300908 Rabbit Monoclonal Antibody against MMP14 (Clone EP1264Y) 100ul $325 In Stock
LC401554 MMP14 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human MMP-14 was used as an immunogen.
Clone NameEP1264Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, FC Suggested DilutionsIHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250; FC: 1:50 - 1:100; IP: 1:100; WB: 1:2000
Predicted MW Explanation 66 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens matrix metallopeptidase 14 (MMP14)
Alternative NameMMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1; WNCHRS
Database LinkNP_004986
Entrez Gene 4323 Human
Entrez Gene 17387 Mouse
Entrez Gene 81707 Rat
FunctionThe matrix metalloproteinase (MMP) family (approximately 25 members in mammals) has been implicated in extracellular matrix remodeling associated with embryonic development, cancer formation and progression, and various other physiological and pathological events. MMP-14 is a membrane-bound matrix metalloproteinase (MT-MMP) capable of mediating pericellular proteolysis of extracellular matrix components. MMP-14 is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix (1). Gelatinase A (type-IV collagenase; M(r) 72,000) is produced by tumour stroma cells and is believed to be crucial for their invasion and metastasis, acting by degrading extracellular matrix macro-molecules such as type IV collagen. MMP-14 may thus trigger invasion by tumor cells by activating pro-gelatinase A on the tumor cell surface (2). Observations identify MT1-MMP as a tumor-derived growth factor that regulates proliferation by controlling cell geometry within the confines of the 3D extracellular matrix (ECM) (3).
Related PathwayTransmembraneProteaseDruggable Genome GnRH signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-MMP14 antibody [EP1264Y]; Anti-MMP14 antibody [EP1264Y] at 1/2000 dilution + Human spleen lysate .Secondary.Goat anti-Rabbit HRP labeled. at 1/2000 dilution.Predicted band size : 66 kDa.Observed band size : 65 kDa .

IHC Image
Immunohistochemistry (Paraffin-embedded sections) - MMP14 antibody [EP1264Y]; Ab51074 (1:100) staining human MMP14 in human breast carcinoma tissue by immunohistochemistry using paraffin embedded tissue.

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MMP14 antibody [EP1264Y]; TA300908 at 1/500 staining human kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step (in Tris/EDTA) was performed. The tissue was then blocked with serum and incubated with the primary antibody. A biotinylated donkey anti-rabbit IgG was used as the secondary.

FC Image
Flow Cytometry - MMP14 antibody; Overlay histogram showing HT1080 cells stained with TA300908 (red line). The secondary antibody used was DyLight 488 goat anti-rabbit IgG (H+L) at 1:500. Isotype control antibody (black line) was rabbit monoclonal IgG (1ug/1x10^6 cells) used under the same conditions. This antibody gave a positive signal in HT1080 cells under the same conditions.


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