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Anti-RPS6KA1 Antibody E4

WB(1)

IHC(1)

IF(1)

FC(1)

Gene Name Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 1 Synonyms: HU-1; MAPKAPK1A; RSK; RSK1 Immunogen A synthetic peptide corresponding to residues in N-terminus of human p90-RSK1 was used as immunogen. Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Clone Name E4 Isotype IgG Species Reactivity Human, Mouse, Rat Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB, IHC, IF, FC Suggested Dilutions WB: 1: 1000; IHC: 1: 100; ICC: 1:200; FC: 1:50; IP: 1: 10 Background RSK 1 (p90-RSK 1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes RSK 1, RSK 2 and RSK 3. These are broadly expressed serine/threonine protein kinases (1) activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). p90-RSK 1 is activated by MAPK in vitro and in vivo via phosphorylation (3). Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4). Related Pathway EGFR1 Signaling Pathway MAPK signaling pathway

Related Lysate from OriGene • Transient overexpression lysate of ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 1 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • RPS6KA1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • RPS6KA1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Rps6ka1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • RPS6KA1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Rps6ka1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 1 as transfection-ready DNA • Lenti ORF clone of Human ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 1 , Myc-DDK-tagged • GFP-tagged ORF clone of Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 1 as transfection-ready DNA • Lenti ORF clone of Human ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 1, mGFP tagged • Myc-DDK-tagged ORF clone of Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 1 as 200 ug transfection-ready DNA Related cDNA Clones • Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 1 as transfection-ready DNA • Kinase deficient mutant (K94M) of Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 1 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)