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Home All anti-MET antibodies

Anti-MET Antibody EP1454Y

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Specifications Related Products Conjugation/Bulk FAQs
SKU Description Amount Price Availability*  
TA300895
  • Rabbit Monoclonal Antibody against MET (Clone EP1454Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400094) , 20ug
100µl $325 In Stock
TA802519S
  • Purified GAPDH mouse monoclonal antibody (Loading control), clone 2D9
30ul
$100
$50*
In Stock
Add to Shopping Cart
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
WB(1)
IHC(1)
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Also for MET (NM_000245)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human Met was used as an immunogen.
Clone NameEP1454Y IsotypeIgG
Species ReactivityHuman Concentration
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:2000; IHC: 1: 100 250; ICC: 1: 100 250
Buffer50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Reference Data

Target NameHomo sapiens met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2
Alternative NameAUTS9; c-Met; HGFR; RCCP2
Database LinkNP_000236
FunctionMet is a receptor protein-tyrosine kinase (RPTK) for hepatocyte growth factor (HGF), which is a multifunctional cytokine controlling cell growth, morphogenesis, and motility. Met overexpression has been identified in a variety of human cancers (1). Met kinase domain possesses unique features that distinguish met from other members of the src family of protein tyrosine kinases. These results also demonstrate that the product of the activated met gene is a fusion protein and that the amino terminal end of this fusion protein exhibits homology to laminin B1 (2). Data suggest that RanBP9, functioning as an adaptor protein for the Met tyrosine kinase domain, can augment the HGF-Met signaling pathway and that RanBP9 overexpression may cause constitutive activation of the Ras signaling pathway (1). Hereditary papillary renal carcinoma (HPRC) is a recently recognized form of inherited kidney cancer Results suggest that missense mutations located in the MET proto-oncogene lead to constitutive activation of the Met protein and papillary renal carcinomas (3)
Related Pathway
Adherens junction
Cytokine-cytokine receptor interaction
Focal Adhesion

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WB Image
Western blot analysis on 293 cell lysate using anti-Met, dilution 1:2000.
IHC Image
Immunohistochemical staining of paraffin-embedded human breast carcinoma using anti-Met.

 

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