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Anti-APOE Antibody EP1373Y
Also for APOE (NM_000041)
|A synthetic peptide corresponding to residues near the N-term of human apolipoprotein E was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:20000; IP: 1:70; FC: 1:30; IHC-P: Use at an assay dependent dilution
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for ICC/IF.
|Homo sapiens apolipoprotein E (APOE), transcript variant 2|
|AD2; APO-E; LDLCQ5; LPG|
Entrez Gene 348 Human
|The apolipoproteins are family of amphipathic lipoproteins that plays a crucial role in lipid metabolism. In particular, apolipoprotein E (apo E) is a major component of high density lipoproteins (HDL) chylomicrons and very low-density lipoprotein (VLDL), which functions to remove excess cholesterol. Apo E mediates lipid metabolism and cholesterol homeostasis by binding to several hepatic lipoprotein receptors, such as low density lipoprotein receptor (LDLR) and the LDLR-related protein (1). Apo E deficiency is linked to hyperlipoproteinemia type III; a genetic disorder characterized by elevated plasma cholesterol and triglyceride levels and accelerated coronary artery disease (2). Three major isoforms of Apo E (E2, E3, E4) has been identified, with E3 being the most common in human. E4 presence has been associated to increase probability of developing late-onset form of Alzheimer disease (3). |
|Secreted ProteinStem cell - PluripotencyAdult stem cellsDruggable Genome Alzheimer's disease|
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Western blot - Apolipoprotein E antibody [EP1373Y]; Anti-Apolipoprotein E antibody [EP1373Y] at 1/10000 dilution + Human serum at 10 ug.Secondary.Goat anti-rabbit HRP labelled at 1/2000 dilution.Predicted band size : 36 kDa.Observed band size : 36 kDa.
Immunohistochemistry (Paraffin-embedded sections) - Apolipoprotein E antibody [EP1373Y]; Ab51015 (1/100) staining Apolioprotein E in human fetal liver tissue by immunohistochemistry using paraffin embedded tissue.