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Home Antibody All anti-APOE antibodies

Anti-APOE Antibody EP1373Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300880
  • Rabbit Monoclonal Antibody against APOE (Clone EP1373Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424959) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for APOE (NM_000041)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-term of human apolipoprotein E was used as an immunogen.
Clone NameEP1373Y IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:20000; IP: 1:70; FC: 1:30; IHC-P: Use at an assay dependent dilution
BufferDoes not react with Mouse, Rat. Is unsuitable for ICC/IF.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for ICC/IF.

Reference Data

Target NameHomo sapiens apolipoprotein E (APOE)
Alternative NameAD2; LDLCQ5; LPG
Database LinkNP_000032
FunctionThe apolipoproteins are family of amphipathic lipoproteins that plays a crucial role in lipid metabolism. In particular, apolipoprotein E (apo E) is a major component of high density lipoproteins (HDL) chylomicrons and very low-density lipoprotein (VLDL), which functions to remove excess cholesterol. Apo E mediates lipid metabolism and cholesterol homeostasis by binding to several hepatic lipoprotein receptors, such as low density lipoprotein receptor (LDLR) and the LDLR-related protein (1). Apo E deficiency is linked to hyperlipoproteinemia type III; a genetic disorder characterized by elevated plasma cholesterol and triglyceride levels and accelerated coronary artery disease (2). Three major isoforms of Apo E (E2, E3, E4) has been identified, with E3 being the most common in human. E4 presence has been associated to increase probability of developing late-onset form of Alzheimer disease (3).
Related Pathway

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WB Image
Western blot - Apolipoprotein E antibody [EP1373Y]; Anti-Apolipoprotein E antibody [EP1373Y] at 1/10000 dilution + Human serum at 10 µg.Secondary.Goat anti-rabbit HRP labelled at 1/2000 dilution.Predicted band size : 36 kDa.Observed band size : 36 kDa.
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Apolipoprotein E antibody [EP1373Y]; Ab51015 (1/100) staining Apolioprotein E in human fetal liver tissue by immunohistochemistry using paraffin embedded tissue.

 

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