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Anti-LDHA Antibody EP1563Y
Also for LDHA (NM_005566)
|A synthetic peptide corresponding to residues in human LDH-A was used as immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||ICC/IF: 1:100 - 1:250; WB: 1:1000 - 1:5000; IP: 1:70; IHC-P: 1:100 - 1:250; FC: 1:30
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Homo sapiens lactate dehydrogenase A (LDHA), transcript variant 1|
|GSD11; HEL-S-133P; LDH1; LDHM; PIG19|
Entrez Gene 3939 Human
Entrez Gene 16828 Mouse
Entrez Gene 24533 Rat
|Lactate dehydrogenase (LDH) is an ubiquitous enzyme commonly found in wide variety of organisms, including plants and microbes. LDH is involved in the interconversion of the pyruvate and NADH to lactate and NAD+. It is also called Hydroxybutyrate Dehydrogenase (HBD), due to the fact that it can catalyze the oxidation of hydroxybutyrate (1). In mammals, three types of LDH subunits (35 kDa) are encoded by the genes Ldh-A, Ldh-B, and Ldh-C, forming various terameric isoenzymes (140 kDa). Lactate dehydrogenase A (LDH-A, muscle subunit, LDH-M) is involved in the final step of anaerobic glycoysis and catalyzes the conversion of L-lactate and NAD to pryruvate and NADH. While it is predominantly expressed in muscle tissue, it is hormonally regulated in rodents and overexpressed during mammary gland tumorigenesis (2). A mutation that cause deficiency in LDH-A has been implicated in exertional myoglobinuria (3). |
|Druggable Genome Glycolysis / GluconeogenesisCysteine and methionine metabolismPyruvate metabolismPropanoate metabolismMetabolic pathways|
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Western blot - Anti-Lactate Dehydrogenase antibody [EP1563Y]; Anti-Lactate Dehydrogenase antibody [EP1563Y] at 1/1000 dilution + A549 cell lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 37 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lactate Dehydrogenase antibody [EP1563Y]; Immunohistochemical analysis of paraffin-embedded Human kidney carcinoma labelling Lactate Dehydrogenase with TA300879 at 1/100 dilution.