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Home Antibody All anti-CRADD antibodies

Anti-CRADD Antibody EPR1640Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300857
  • Rabbit Monoclonal Antibody against CRADD (Clone EPR1640Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401252) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for CRADD (NM_003805)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human RAIDD was used as an immunogen
Clone NameEPR1640Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1: 1000; IHC: 1:50 100; ICC: 1: 100 250; FC: 1:20; IP: 1:30
Predicted MW Explanation 23 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens CASP2 and RIPK1 domain containing adaptor with death domain (CRADD)
Alternative NameMRT34; RAIDD
Database LinkNP_003796
Entrez Gene 8738 Human
FunctionApoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the inactive zymogen, as occurs in the caspase-9-activating apoptosome complex. Activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD (1). RAIDD has a dual-domain structure similar to that of FADD. It has an NH2-terminal caspase homology domain that interacts with caspase-2 and a COOH-terminal DD that interacts with RIP. RAIDD is constitutively expressed in many tissues and thus could play a role in regulating apoptosis in mammalian cells (2). In metazoan cells there exists inactive polypeptide precursors (zymogens), each composed of a prodomain, which is cleaved to activate the protease, and a large and small catalytic subunit. The coupling of these 'death' proteases to signaling pathways is probably mediated by adaptor molecules that contain protein-protein interaction motifs such as the death domain (3).
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - RAIDD antibody [EPR1640Y]; Anti-RAIDD antibody [EPR1640Y] at 1/1000 dilution + HeLa cell lysate at 10 ug.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 23 kDa.Observed band size : 23 kDa.
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - RAIDD antibody [EPR1640Y]; TA300857, at a 1/50 dilution, staining Human RAIDD in heart muscle, using Immunohistochemistry, Paraffin embedded tissue.

 

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