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Anti-CDK5 Antibody EP762RY


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against CDK5 (Clone EP762RY)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401536) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the tyrosine 15 of human Cdk5 protein.
Clone NameEP762RY IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:2000; IHC-P: Use at an assay dependent dilution
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens cyclin-dependent kinase 5 (CDK5), transcript variant 1
Alternative NamePSSALRE
Database LinkNP_004926
Entrez Gene 1020 Human
FunctionCyclin-dependent protein kinase 5 (Cdk5) is a unique member of the family of cyclin-dependent kinases that is not directly involved in the progression of proliferating cells through the cell cycle (1). Distributed in most tissues and various cell lines, Cdk5 is active primarily in neuronal tissues, because of its association with neuron-specific activators such as p35 (a neural-specific regulatory subunit of Cdk5) (2). In addition to its role in muscle and neuronal differentiation, Cdk5 also contributes to the assembly, organization and stability of the axonal cytoskeleton in neurons, promotes neurite outgrowth and axon guidance in developing neurons, participates in the regulation of synaptic transmission and provides an additional pathway to cellular apoptosis (3-5). Cdk5 phosphorylates MAP1b, Tau, neurofilament proteins, caldesmon and proteins of the synaptic vesicles. Deregulation of Cdk5 has profound cytotoxic effects and is implicated in the development of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis. Recent studies have showed that increased kinase activity of the p35/Cdk5 complex in developing neurons is observed when Cdk5 is phosphorylated at Y15 by c-Abl tyrosine kinase; this activity is further enhanced by Cable (6).
Related PathwayProtein KinaseDruggable Genome Axon guidanceAlzheimer's disease

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Western blot - Anti-Cdk5 (phospho Y15) antibody [EP762RY]; Lanes 1 - 2 : Pan Cdk5.Lanes 3 - 4 : Anti-Cdk5 (phospho Y15) antibody [EP762RY] at 1/2000 dilution.Lane 1 : HeLa cell lysate treated with AP.Lane 2 : HeLa cell lysate.Lane 3 : HeLa cell lysate treated with AP.Lane 4 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 33 kDa.Observed band size : 33 kDa.Additional bands at : 160 kDa. We are unsure as to the identity of these extra bands.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cdk5 (phospho Y15) antibody [EP762RY]; TA300847, at 1/50 dilution, staining Cdk5 in paraffin embedded human brain tissue sections by Immunohistochemistry.


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