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Anti-MMP20 Antibody EP1275Y


Specifications Citations (1) Related Products Product Documents
SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against MMP20 (Clone EP1275Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417767) , 20ug Explanation
100ul $325 3-7 Days
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Also for MMP20 (NM_004771)
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human MMP-20 was used as an immunogen.
Clone NameEP1275Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsICC/IF: 1:100 - 1:250; WB: 1:500
Predicted MW Explanation 54 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens matrix metallopeptidase 20 (MMP20)
Alternative NameAI2A2; MMP-20
Database LinkNP_004762
Entrez Gene 9313 Human
Entrez Gene 30800 Mouse
Entrez Gene 300341 Rat
FunctionMMP-20 (enamelysin) is a recently discovered member of the MMP family. This enzyme is involved in the degradation of the various components of the extracellular matrix (ECM) during development, haemostasis and pathological conditions. MMP-20 expression has been found to be restricted to the enamel organ and due to its unique expression pattern, may primarily be involved in the turnover of these molecules during tooth development. The enamel matrix proteins amelogenin, ameloblastin, and enamelin are expressed during the developmental time period, suggesting that MMP-20 may play a role in their hydrolysis (1). Recombinant human enamelysin is able to degrade amelogenin, the major protein component of the enamel matrix. On the basis of its degrading activity on amelogenin, and its highly restricted expression to dental tissues, we suggest that human enamelysin plays a central role in the process of tooth enamel formation (2). Enamelysin null mice do not process amelogenin properly, possesses an altered enamel matrix and rod pattern, has hypoplastic enamel that delaminates from the dentin, and has a deteriorating enamel organ morphology as development progresses (3).
Related PathwaySecreted ProteinTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - MMP20 antibody [EP1275Y]; Anti-MMP20 antibody [EP1275Y] at 1/500 dilution + HeLa cell lysate at 10 ug.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 54 kDa.Observed band size : 54 kDa.
Immunocytochemistry/ Immunofluorescence - MMP20 antibody [EP1275Y]; TA300846 at 1/100-1/250 dilution staining MMP20 in HeLa cells by Immunofluorescence.


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