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Home Antibody All anti-KRT5 antibodies

Anti-KRT5 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300834
  • Rabbit Polyclonal Antibody against KRT5
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400149) , 20ug
100ul 379 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human CK-5 was used as an immunogen.
Clone Name IsotypeProtein A purified
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000; ICC/IF: 1:50 - 1:100; IHC-P: 1:50 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens keratin 5 (KRT5)
Alternative NameCK5; DDD; DDD1; EBS2; K5; KRT5A
Database LinkNP_000415
FunctionKeratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. The mitotically active basal layers of most stratified squamous epithelia express 10 to 30% of their total protein as keratin. The two keratins specifically expressed in these cells are the type II keratin CK-5 and its corresponding partner, type I keratin CK-14, both of which are essential for the formation of 8-nm filaments (1). CK-5 and calretinin have been useful in different studies as immunohistochemical markers suggestive of mesothelioma, and their expression is analyzed for the histological differential diagnosis with adenocarcinomas, especially when confronting with metastatic tumors of unknown origin (2). Loss-of-function mutations in the keratin 5 gene (KRT5) affected family members and in six unrelated patients with Dowling-Degos disease (DDD), an autosomal dominant genodermatosis. This suggests a crucial role for keratins in the organization of cell adhesion, melanosome uptake, organelle transport, and nuclear anchorage (3).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Cytokeratin 5 antibody; Anti-Cytokeratin 5 antibody at 1/1000 dilution + A431 cell lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 62 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 5 antibody; Immunohistochemical analysis of paraffin embedded Human transitional carcinoma of bladder tissue labelling Cytokeratin 5 with TA300834 antibody at a dilution of 1/50.

 

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