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Anti-APOE Antibody EP1374Y
Also for APOE (NM_000041)
|A synthetic peptide corresponding to residues near the C-term of human apolipoprotein E was used as an immunogen.|
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||WB: 1:1000 - 1:10000; IP: 1:100; IHC-P: 1:100 - 1:250; ICC/IF: 1:250 - 1:500
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens apolipoprotein E (APOE)|
|AD2; LDLCQ5; LPG|
|The apolipoproteins are family of amphipathic lipoproteins that plays a crucial role in lipid metabolism. In particular, apolipoprotein E (apo E) is a major component of high density lipoproteins (HDL) chylomicrons and very low-density lipoprotein (VLDL), which functions to remove excess cholesterol. Apo E mediates lipid metabolism and cholesterol homeostasis by binding to several hepatic lipoprotein receptors, such as low density lipoprotein receptor (LDLR) and the LDLR-related protein (1). Apo E deficiency is linked to hyperlipoproteinemia type III; a genetic disorder characterized by elevated plasma cholesterol and triglyceride levels and accelerated coronary artery disease (2). Three major isoforms of Apo E (E2, E3, E4) has been identified, with E3 being the most common in human. E4 presence has been associated to increase probability of developing late-onset form of Alzheimer disease (3). |
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Western blot - Apolipoprotein E antibody [EP1374Y]; Anti-Apolipoprotein E antibody [EP1374Y] at 1/20000 dilution + Human serum at 10 µg.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 36 kDa.Observed band size : 36 kDa.
Immunohistochemistry (Paraffin-embedded sections) - Apolipoprotein E antibody [EP1374Y]; Immunohistochemical analysis of paraffin-embedded human normal liver using TA300831 at a dilution of 1/100-1/250.
Immunocytochemistry/ Immunofluorescence - Apolipoprotein E antibody [EP1374Y]; Immunofluorescent staining of HepG2 cells using TA300831 at a dilution of 1/250-1/500.