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Anti-EZR Antibody EP925Y
|A synthetic phospho-specific peptide corresponding to residues surrounding Tyr353 of human Ezrin was used as an immunogen. The antibody only detects Ezrin phosphorylated on Tyrosine 353.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
|Does not react with Mouse, Rat. Is unsuitable for ICC/IF,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for ICC/IF,IHC-P or IP.
|Homo sapiens ezrin (EZR), transcript variant 1|
|CVIL; CVL; HEL-S-105; VIL2|
|Erzin, a member of the Ezrin, Radixin, Moesin (ERM) family, is a linker protein located between cell surface receptors, adhesion molecules, and actin cytoskeleton (1-2). Ezrin activity is regulated by intramolecular interactions between N- and C-terminal ERM association domains (3). Phosphorylation at threonine 567 is a critical regulator of Ezrin function allowing the active protein to link target molecules to the actin cytoskeleton (4). Erzin tyrosine phosphorylation can also be induced by EGF, PDGF and HGF stimulation. Erzin interacts with PI3-K protein kinase A and Rho (5). |
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Western blot - Ezrin (phospho Y353) antibody [EP925Y]; All lanes : Anti-Ezrin (phospho Y353) antibody [EP925Y] at 1/200000 dilution.Lane 1 : 293 cell lysate untreated.Lane 2 : 293 cell lysate treated with pervanadate.Lysates/proteins at 10 µg per lane.Predicted band size : 69 kDa.Observed band size : 69 kDa.