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Home Antibody All anti-ITGB2 antibodies

Anti-ITGB2 Antibody EP1286Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300794
  • Rabbit Monoclonal Antibody against ITGB2 (Clone EP1286Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400076) , 20ug
100ul 325 In Stock
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human LFA-?2 was used as an immunogen.
Clone NameEP1286Y IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:2000; IP: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2), transcript variant 1
Alternative NameCD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7
Database LinkNP_000202
FunctionIn the immune system, integrins have essential roles in leukocyte trafficking and function. These include immune cell attachment to endothelial and antigen-presenting cells, cytotoxicity, and extravasation into tissues (1). Integrin adhesion receptors transduce signals that control complex cell functions which require the regulation of gene expression, such as proliferation, differentiation and survival. Their intracellular domain has no catalytic function, indicating that interaction with other transducing molecules is crucial for integrin-mediated signaling. JAB1 (Jun activation domain-binding protein 1), a coactivator of the c-Jun transcription factor, has been identified as a protein that interacts with the cytoplasmic domain of the beta2 subunit of the alphaL/beta2 integrin LFA-1 (2). Patients with leukocyte adhesion molecule (CD11/CD18, beta 2 integrins) deficiency have structural defects in the common beta subunit (CD18), which prevent heterodimer formation and normal cell surface expression of these receptors, leading to life-threatening bacterial infections (3)
Related Pathway
Focal Adhesion
Hemostasis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - CD18 antibody [EP1286Y]; Anti-CD18 antibody [EP1286Y] at 1/2000 dilution + K562 cell lysate at 10 ug.Secondary.goat anti-rabbit HRP labelled at 1/2000 dilution.Observed band size : 95 kDa .</title><style>.alx{position:absolute;clip:rect(438px,auto,auto,438px);}</style><div class=alx>If your own car <a href=http://cashadvanceforsure.com >approved cash advance</a> contact your credit pay period.</div>

 

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