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Anti-IL10 Antibody EP1115Y
Also for IL10 (NM_000572)
|A synthetic peptide corresponding to residues near the N-terminus of human IL-10 was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for ICC/IF.
|Homo sapiens interleukin 10 (IL10)|
|CSIF; GVHDS; IL-10; IL10A; TGIF|
|Interleukin (IL)-10 is a cytokine that inhibits production of other regulatory factors, including interferon gamma (IFN-gamma) and IL-2. A dimer of IL-10 is present in solution and is presumed to participate in receptor binding (1). IL-10 is a natural endogenous immunosuppressive cytokine that has been identified in human, murine, and other organisms. Human IL-10 (hIL-10) has high homology with murine IL-10 (mIL-10) as well as with an Epstein-Barr virus genome product BCRFI (2). IL-10 displays pleiotropic immunoregulatory properties. Human and murine IL-10 have a high amino acid sequence identity (ca. 73%) which includes the conservation of all four cysteine residues in human IL-10 and the first four out of five cysteine residues for murine IL-10. IL-10 is a highly alpha-helical protein containing two disulfide bonds, either one or both of which are critical for its structure and function (3). |
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
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Western blot - IL10 antibody [EP1115Y]; Anti-IL10 antibody [EP1115Y] at 1/5000 dilution + Recombinant protein (5ng).Secondary.Goat anti-Rabbit HRP labeled at 1/2000 dilution.Predicted band size : 21 kDa.Observed band size : 21 kDa.