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Home Antibody All anti-HNRNPK antibodies

Anti-HNRNPK Antibody EP943Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300758
  • Rabbit Monoclonal Antibody against HNRNPK (Clone EP943Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400779) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for HNRNPK (NM_002140)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human hnRNP was used as an immunogen. This antibody detects both phosphorylated and unphosphorylated hnRNP K.
Clone NameEP943Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:100000; IP: 1:50; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:100 - 1:250
Predicted MW Explanation 51 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens heterogeneous nuclear ribonucleoprotein K (HNRNPK), transcript variant 1
Alternative NameCSBP; HNRPK; TUNP
Database LinkNP_002131
Entrez Gene 3190 Human
Entrez Gene 15387 Mouse
Entrez Gene 117282 Rat
FunctionThe hnRNP-K family of acidic nuclear proteins has been identified using a monoclonal antibody that distinguishes between quiescent and proliferating human keratinocytes. The family, which is composed of four major proteins (hnRNPs-K A, B, C and D) and their modified forms, is present in similar overall levels in quiescent and proliferating normal keratinocytes although clear differences were observed in the levels of some of the individual variants (1). hnRNP-K is an ancient RNA/DNA-binding protein that is involved in multiple processes that compose gene expression. The pleiotropic action of K protein reflects its ability to interact with different classes of factors, interactions that are regulated by extracellular signals (2). hnRNP-K has several different cellular roles including transcription, mRNA shuttling, RNA editing and translation. Several reports implicate hnRNP K having a role in tumorigenesis, for instance hnRNP K increases transcription of the oncogene c-myc and hnRNP K expression is regulated by the p53/MDM 2 pathway (3).
Related Pathway Spliceosome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - hnRNP K antibody [EP943Y]; Anti-hnRNP K antibody [EP943Y] at 1/100000 dilution + Jurkat cell lysate at 10 ug.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 51 kDa.Observed band size : ~60 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - hnRNP K antibody [EP943Y]; Immunohistochemical staining of paraffin-embedded human breast carcinoma tissue using TA300758 at a dilution of 1/100-1/250.
IF Image
Immunocytochemistry/ Immunofluorescence - hnRNP K antibody [EP943Y]; Fluorescent immunostaining of HeLa cells using TA300758 at a dilution of 1/100-1/250.

 

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