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Anti-F11R Antibody EP1042Y
Also for F11R (NM_144504)
|A synthetic peptide corresponding to residues near the N-terminus of human JAM1 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC or IP.
|Homo sapiens F11 receptor (F11R), transcript variant 5|
|JAM, KAT, JAM1, JAMA, JCAM, CD321, JAM-1, JAM-A, PAM-1|
|Junctional Adhesion Molecules (JAMs) are components and regulators of the well-characterized epithelial and endothelial tight junction. JAM is selectively concentrated at intercellular junctions of endothelial and epithelial cells of different origins. Microscopy shows that JAM codistributes with tight junction components at the apical region of the intercellular cleft. A mAb directed to JAM (BV11) was found to inhibit spontaneous and chemokine-induced monocyte transmigration through an endothelial cell monolayer in vitro. Systemic treatment of mice with BV11 mAb blocked monocyte infiltration upon chemokine administration in subcutaneous air pouches (1). The human protein shares a highly conserved structure and sequence with the murine protein. However it is distinct in that it is constitutively expressed on circulating neutrophils, monocytes, platelets and lymphocyte subsets (2). |
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Western blot - Junctional Adhesion Molecule 1 antibody [EP1042Y]; Anti-Junctional Adhesion Molecule 1 antibody [EP1042Y] at 1/2000 dilution + Hela cell lysate at 10 µg.Secondary.Goat anti-rabbit HRP labeled at 1/2000 dilution.Predicted band size : 33 kDa.Observed band size : 33 kDa.
Immunohistochemistry (Paraffin-embedded sections) - Junctional Adhesion Molecule 1 antibody [EP1042Y]; Immunohistochemical staining of paraffin-embedded human liver using ab52647 at a 1/100 dilution.