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Anti-IFNG Antibody EP1109Y
Also for IFNG (NM_000619)
|A synthetic peptide corresponding to residues human IFN- was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens interferon, gamma (IFNG)|
Entrez Gene 3458 Human
|Interferons (IFNs) plays a crucial role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. In particular, Interferon gamma (IFN-?), a sole member of Type II IFN family, is involved in the lymphocyte activation and the regulation of lymphocyte subsets (proliferation, differentiation) (1). IFN-? is expressed in activated CD4 Th1 cells, CD8 cells, gamma/delta T cells, and activated NK cells. IFN-? expression is induced by IL-2, TNF-a and IL-12 and suppressed by IL-4, IL-10, and TGF-ß (2). IFN-? binds to IFN-? receptor (IFNGR) which stimulates various immuno-responses, such as macrophages activation and enhancement of the type I IFNs anti-viral and anti-tumor activities. In immunocompetent host cells, IFN-? protects against tumor development and directs immunogenic phenotype (3). IFN-? has been implicated various human diseases, such as multiple sclerosis and insulin-dependent diabetes mellitus (4). |
|Secreted ProteinDruggable Genome ProteasomeCytokine-cytokine receptor interactionRegulation of autophagyTGF-beta signaling pathwayJak-STAT signaling pathwayNatural killer cell mediated cytotoxicityMore Pathways >> |
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Western blot - Interferon gamma antibody [EP1109Y]; Anti-Interferon gamma antibody [EP1109Y] at 1/2000 dilution + recombinant protein at 0.01 ug.Secondary.Goat anti-rabbit HRP labeled at 1/2000 dilution.Predicted band size : 19 kDa.Observed band size : 17 kDa .