Home Antibody All anti-ACLY antibodies
Anti-ACLY Antibody EP828Y
Also for ACLY (NM_001096)
|A synthetic peptide corresponding to residues of human ATP citrate lyase was used as immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:5000; IP: 1:20
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens ATP citrate lyase (ACLY), transcript variant 1|
|ACL; ATPCL; CLATP|
Entrez Gene 47 Human
Entrez Gene 104112 Mouse
Entrez Gene 24159 Rat
|ATP citrate lyase (ACL) is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer of four identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. One of these products, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. NDPK has been found to phosphorylate ACL and insulin to increase phosphorylation of ACL (2).|
|Druggable Genome Citrate cycle (TCA cycle)Metabolic pathways|
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Western blot - ATP citrate lyase (phospho S455) antibody [EP828Y]; All lanes : Anti-ATP citrate lyase (phospho S455) antibody [EP828Y] at 1/5000 dilution.Lane 1 : Untreated 3T3 cell lysates.Lane 2 : Insulin treated 3T3 cell lysates.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Observed band size : 125 kDa .