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Home Antibody All anti-TUBB antibodies

Anti-TUBB Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300713
  • Rabbit Polyclonal Antibody against TUBB
  • FREE positive control: HEK293T cell transient overexpression lysate (LC403597) , 20ug
100ul 379 In Stock
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WB(1)
IHC(1)
IF(1)
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Also for TUBB (NM_178014)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-term of human B-Tubulin was used as immunogen.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsIHC-P: 1:100 - 1:250; WB: 1:1000 - 1:2000; IP: 1:50; ICC/IF: 1:50 - 1:100
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Protein A purified
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens tubulin, beta class I (TUBB)
Alternative NameCDCBM6; M40; OK/SW-cl.56; TUBB1; TUBB5
Database LinkNP_821133
FunctionMicrotubules are essential parts in eukaryotic cell structures, transportation, and mitosis and consists mainly of 2 soluble protein subunits, alpha and beta tubulin. Beta-tubulin binds to alpha tubulin to form tubulin heterodimer which is post-translationally modified (1). The tubulin dimer complex binds to GTP and assembles onto the positive ends of microtubules. After incorporation into the microtubules, bound GTP is hydrolyzed by beta tubulin. The stability of the dimer in the microtubules is depended on presence of beta tubulin, where dimer with GTP bound beta-tubulin is stable to microtubule incorporation (2). Mutation on beta-tubulin has been linked to anti-cancer drug resistance in lung cancers (3).
Related Pathway
Cell cycle

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WB Image
Western blot - Anti-beta Tubulin antibody; Anti-beta Tubulin antibody at 1/1000 dilution + HeLa cell lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 49 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta Tubulin antibody; Immunohistochemical analysis of paraffin-embedded Human muscle tissue labelling beta Tubulin with TA300713 at 1/100 dilution.
IF Image
Immunocytochemistry/ Immunofluorescence - Anti-beta Tubulin antibody; Immunofluorescent analysis of HeLa cells labelling beta Tubulin with TA300713 at 1/50 dilution.

 

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