Anti-TNF Antibody,

Also for TNF (NM_000594)

Gene Name	Homo sapiens tumor necrosis factor (TNF)
Synonyms:	DIF; TNF-alpha; TNFA; TNFSF2
Immunogen	A recombinant human TNF-a was used as an immunogen.
Buffer	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Clone Name		Isotype	IgG
Species Reactivity	Human	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:5000
Background	Tumor necrosis factor is a multifunctional proinflammatory cytokine, with effects on lipid metabolism, coagulation, insulin resistance, and endothelial function. Tumor necrosis factor-alpha (TNF-a), the product of activated monocytes, is secreted by macrophages in response to inflammation, infection and cancer (1). TNF-a triggers a signaling cascade, converging on the activation of the transcription factor NF-kappa B, which forms the basis for numerous physiological and pathological processes (2). TNF-a has been shown to play a role in systems such as the pathogenesis of psoriasis, tuberculosis, obesity, cerebral malaria, rheumatoid arthritis and asthma (3).
Related Pathway	Adipogenesis Apoptosis Cytokine-cytokine receptor interaction Hematopoietic cell lineage MAPK signaling pathway TGF Beta Signaling Pathway Toll-like receptor signaling pathway

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WB Image

Western blot analysis using anti-TNF-α, dilution 1:5000.

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Anti-TNF Antibody

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