Tumor necrosis factor is a multifunctional proinflammatory cytokine, with effects on lipid metabolism, coagulation, insulin resistance, and endothelial function. Tumor necrosis factor-alpha (TNF-a), the product of activated monocytes, is secreted by macrophages in response to inflammation, infection and cancer (1). TNF-a triggers a signaling cascade, converging on the activation of the transcription factor NF-kappa B, which forms the basis for numerous physiological and pathological processes (2). TNF-a has been shown to play a role in systems such as the pathogenesis of psoriasis, tuberculosis, obesity, cerebral malaria, rheumatoid arthritis and asthma (3).
Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
MAPK signaling pathway
TGF Beta Signaling Pathway
Toll-like receptor signaling pathway
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