Home Antibody All anti-TNF antibodies
|A recombinant human TNF-a was used as an immunogen.|
||Protein A purified
||Lot dependent; please refer to CoA along with shipment
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.|
|Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
|Homo sapiens tumor necrosis factor (TNF)|
|DIF; TNF-alpha; TNFA; TNFSF2|
|Tumor necrosis factor is a multifunctional proinflammatory cytokine, with effects on lipid metabolism, coagulation, insulin resistance, and endothelial function. Tumor necrosis factor-alpha (TNF-a), the product of activated monocytes, is secreted by macrophages in response to inflammation, infection and cancer (1). TNF-a triggers a signaling cascade, converging on the activation of the transcription factor NF-kappa B, which forms the basis for numerous physiological and pathological processes (2). TNF-a has been shown to play a role in systems such as the pathogenesis of psoriasis, tuberculosis, obesity, cerebral malaria, rheumatoid arthritis and asthma (3). |
Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
MAPK signaling pathway
TGF Beta Signaling Pathway
Toll-like receptor signaling pathway
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Western blot - Anti-TNF alpha antibody; Anti-TNF alpha antibody at 1/5000 dilution + recombinant TNF alpha protein at 0.01 µg.Predicted band size : 25 kDa.Observed band size : 17.5 kDa .