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Home Antibody All anti-FCGR2B antibodies

Anti-FCGR2B Antibody EP888Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300701
  • Rabbit Monoclonal Antibody against FCGR2B (Clone EP888Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400365) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for FCGR2B (NM_001002275)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues at the C-terminus of human Fc-gamma RII-b was used as an immunogen.
Clone NameEP888Y IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:50000; IHC-P: Use at an assay dependent dilution; FC: 1:20; IP: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B), transcript variant 4
Alternative NameCD32; CD32B; FCG2; FCGR2; IGFR2
Database LinkNP_001002275
FunctionLow affinity IgG Fc receptor gamma II (Fc-gamma II), also known as CD32, is a member of the immunoreceptor tyrosine-based activating/inhibitory motif (ITAM/ITIM) family. Fc gamma receptors play a critical role in immunity by linking the IgG antibody mediated response with the regulatory functions of the immune system (1). Three classes of Fc gamma receptor exist; Fc gamma RI (CD64, a high affinity receptor), Fc gamma RII, and RIII (CD32 and CD16 respectively, both low affinity receptors). Fc gamma RIIa is an activating receptor, while RIIb1, RIIb2, and RIIb3 are inhibitory receptors generated by alternative splicing (1-2). Fc gamma RIIa is critical for antigen-presenting-cell activation and Fc gamma RIIb downregulates B-cell functions (3). Fc gamma RIIb has also been known to block the inflammatory immune response in mice (4). Once phosphorylated on tyrosine residues, Fc gamma RIIb associates with SHIP to downregulate phagocytosis.
Related Pathway

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WB Image
Western blot - CD32 antibody [EP888Y]; Anti-CD32 antibody [EP888Y] at 1/50000 dilution + 10 ug Daudi cell lysate .Secondary.Goat anti rabbit HRP 1/2000.Observed band size : 49-55 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - CD32 antibody [EP888Y]; Ab45143 staining human CD32 (1/100) in human lymph node by immunohistochemistry using paraffin embedded tissue.

 

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