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Anti-FCGR2B Antibody EP888Y

WB(1)

IHC(1)

Gene Name Homo sapiens Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B), transcript variant 4 Synonyms: CD32; CD32B; FCG2; FCGR2; IGFR2 Immunogen A synthetic peptide corresponding to residues at the C-terminus of human Fc-gamma RII-b was used as an immunogen. Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Clone Name EP888Y Isotype IgG Species Reactivity Human Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB, IHC Suggested Dilutions WB: 1:5,000~50,000; IHC: 1: 100-250; FC: 1:20; IP: 1:50 Background Low affinity IgG Fc receptor gamma II (Fc-gamma II), also known as CD32, is a member of the immunoreceptor tyrosine-based activating/inhibitory motif (ITAM/ITIM) family. Fc gamma receptors play a critical role in immunity by linking the IgG antibody mediated response with the regulatory functions of the immune system (1). Three classes of Fc gamma receptor exist; Fc gamma RI (CD64, a high affinity receptor), Fc gamma RII, and RIII (CD32 and CD16 respectively, both low affinity receptors). Fc gamma RIIa is an activating receptor, while RIIb1, RIIb2, and RIIb3 are inhibitory receptors generated by alternative splicing (1-2). Fc gamma RIIa is critical for antigen-presenting-cell activation and Fc gamma RIIb downregulates B-cell functions (3). Fc gamma RIIb has also been known to block the inflammatory immune response in mice (4). Once phosphorylated on tyrosine residues, Fc gamma RIIb associates with SHIP to downregulate phagocytosis. Related Pathway

Related Lysate from OriGene • Transient overexpression lysate of Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B), transcript variant 4 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • FCGR2B - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • FCGR2B - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Fcgr2b - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • FCGR2B - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Fcgr2b - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B), transcript variant 4 as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B), transcript variant 4 as transfection-ready DNA • Lenti ORF clone of Human Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B), transcript variant 4 , Myc-DDK-tagged • Lenti ORF clone of Human Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B), transcript variant 4, mGFP tagged • Myc-DDK-tagged ORF clone of Homo sapiens Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B), transcript variant 4 as 200 ug transfection-ready DNA Related cDNA Clones • Homo sapiens Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B), transcript variant 4 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)