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Home Antibody All anti-FCGR2B antibodies

Anti-FCGR2B Antibody EP888Y


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA300701 Rabbit Monoclonal Antibody against FCGR2B (Clone EP888Y) 100ul $325 In Stock
LC400365 FCGR2B HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for FCGR2B (NM_001002275)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues at the C-terminus of human Fc-gamma RII-b was used as an immunogen.
Clone NameEP888Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:50000; IHC-P: Use at an assay dependent dilution; FC: 1:20; IP: 1:50
Predicted MW Explanation 40-44 kDa (3 isoforms)
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B), transcript variant 4
Alternative NameCD32; CD32B; FCG2; FCGR2; IGFR2
Database LinkNP_001002275
Entrez Gene 2213 Human
FunctionLow affinity IgG Fc receptor gamma II (Fc-gamma II), also known as CD32, is a member of the immunoreceptor tyrosine-based activating/inhibitory motif (ITAM/ITIM) family. Fc gamma receptors play a critical role in immunity by linking the IgG antibody mediated response with the regulatory functions of the immune system (1). Three classes of Fc gamma receptor exist; Fc gamma RI (CD64, a high affinity receptor), Fc gamma RII, and RIII (CD32 and CD16 respectively, both low affinity receptors). Fc gamma RIIa is an activating receptor, while RIIb1, RIIb2, and RIIb3 are inhibitory receptors generated by alternative splicing (1-2). Fc gamma RIIa is critical for antigen-presenting-cell activation and Fc gamma RIIb downregulates B-cell functions (3). Fc gamma RIIb has also been known to block the inflammatory immune response in mice (4). Once phosphorylated on tyrosine residues, Fc gamma RIIb associates with SHIP to downregulate phagocytosis.
Related PathwayES Cell Differentiation/IPSTransmembrane B cell receptor signaling pathwayFc gamma R-mediated phagocytosisSystemic lupus erythematosus

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - CD32 antibody [EP888Y]; Anti-CD32 antibody [EP888Y] at 1/50000 dilution + 10 ug Daudi cell lysate .Secondary.Goat anti rabbit HRP 1/2000.Observed band size : 49-55 kDa .
Immunohistochemistry (Paraffin-embedded sections) - CD32 antibody [EP888Y]; Ab45143 staining human CD32 (1/100) in human lymph node by immunohistochemistry using paraffin embedded tissue.


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