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Home Antibody All anti-VTN antibodies

Anti-VTN Antibody EP873Y


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA300697 Rabbit Monoclonal Antibody against VTN (Clone EP873Y) 100ul $325 In Stock
LC400215 VTN HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the V10 subunit of human vitronectin was used as an immunogen.
Clone NameEP873Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:2000 - 1:10000; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:50 - 1:100
Predicted MW Explanation 75 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens vitronectin (VTN)
Alternative NameV75; VN; VNT
Database LinkNP_000629
Entrez Gene 7448 Human
Entrez Gene 22370 Mouse
Entrez Gene 29169 Rat
FunctionVitronectin, a 75 kDa polypeptide along with a 10 kDa fragment, is a glycoprotein present on most cell surfaces, in extracellular fluids and plasma (1). Vitronectin promotes cellular adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors (2). As a member of the integrin family, Vitronectin contains the cell binding sequence arg gly asp (RGD), first found in fibronectin, and serves as a cell-to-substrate adhesion molecule (3). Vitronectin acts as an inhibitor of the complement cascade by binding to the C5b9 complex and it has also been shown to have has a novel and direct role in self-senescent-self intercellular recognition leading to macrophage phagocytosis of cells undergoing apoptosis (4).
Related PathwaySecreted ProteinDruggable Genome Focal adhesionECM-receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Vitronectin antibody [EP873Y]; Anti-Vitronectin antibody [EP873Y] at 1/20000 dilution + Hu Serum membrane at 10 ug.Secondary.Goat anti-rabbit HRP labelled, at 1/2000 dilution.Observed band size : 75 kDa .

IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Vitronectin antibody [EP873Y]; Ab45139 at a 1/100 dilution, staining human Vitronectin in human liver tissue by immunohistochemistry using paraffin embedded tissue.


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