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Home Antibody All anti-VTN antibodies

Anti-VTN Antibody EP873Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300697
  • Rabbit Monoclonal Antibody against VTN (Clone EP873Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400215) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for VTN (NM_000638)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the V10 subunit of human vitronectin was used as an immunogen.
Clone NameEP873Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:2000 - 1:10000; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:50 - 1:100
Predicted MW Explanation 75 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens vitronectin (VTN)
Alternative NameV75; VN; VNT
Database LinkNP_000629
Entrez Gene 7448 Human
Entrez Gene 22370 Mouse
Entrez Gene 29169 Rat
FunctionVitronectin, a 75 kDa polypeptide along with a 10 kDa fragment, is a glycoprotein present on most cell surfaces, in extracellular fluids and plasma (1). Vitronectin promotes cellular adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors (2). As a member of the integrin family, Vitronectin contains the cell binding sequence arg gly asp (RGD), first found in fibronectin, and serves as a cell-to-substrate adhesion molecule (3). Vitronectin acts as an inhibitor of the complement cascade by binding to the C5b9 complex and it has also been shown to have has a novel and direct role in self-senescent-self intercellular recognition leading to macrophage phagocytosis of cells undergoing apoptosis (4).
Related PathwaySecreted ProteinDruggable Genome Focal adhesionECM-receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Vitronectin antibody [EP873Y]; Anti-Vitronectin antibody [EP873Y] at 1/20000 dilution + Hu Serum membrane at 10 ug.Secondary.Goat anti-rabbit HRP labelled, at 1/2000 dilution.Observed band size : 75 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Vitronectin antibody [EP873Y]; Ab45139 at a 1/100 dilution, staining human Vitronectin in human liver tissue by immunohistochemistry using paraffin embedded tissue.

 

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