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Anti-TSC1 Antibody EP318Y


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA300662 Rabbit Monoclonal Antibody against TSC1 (Clone EP318Y) 100ul $325 In Stock
LC400132 TSC1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to C-terminal residues of human TSC1/Hamartin was used as an immunogen.
Clone NameEP318Y IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:20000; IHC-P: Use at an assay dependent dilution
Predicted MW Explanation 150 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens tuberous sclerosis 1 (TSC1), transcript variant 1
Alternative NameLAM; TSC
Database LinkNP_000359
Entrez Gene 7248 Human
FunctionTuberous sclerosis complexes-1 (TCS1 also known as Hamartin) is a tumor suppressor that form a complex with TSC2 (Tuberin. This complex is known to control various cellular functions including cell cycle, endocytosis, adhesion, and transcription (1). The TSC1/TSC2 complex inhibits phosphorylation of S6kinase and 4E-BP1 through inactivation of mTOR (2). Recently it has been shown that TSC1/Hamartin is localized to the centrosome and negatively regulates Plk1 implicating TSC1/hamartin to the regulation of centrosome duplication (3). Tuberous sclerosis (TSC), an autosomal dominant disorder that affects 1 in 6000 individuals, is caused by a mutation in either the TSC1 or TSC2 tumor suppressor gene.
Related Pathway mTOR signaling pathwayInsulin signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Hamartin antibody [EP318Y]; Anti-Hamartin antibody [EP318Y] at 1/20000 dilution + HeLa cell lysate.Predicted band size : 150 kDa.Observed band size : 150 kDa.

IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Hamartin antibody [EP318Y]; Ab40872 staining human Hamartin in human kidneys by immunohistochemistry using paraffin embedded tissue.


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