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Anti-GRM1 Antibody EP691Y
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for GRM1 (NM_001274)
|A synthetic peptide corresponding to C-terminal residues of human Chk1 was used as an immunogen.|
||WB: 1: 10,000; IHC: 1:250 500; ICC: 1: 100 250; FC: 1: 160
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 3|
|Chk1 is involved in cell cycle arrest when DNA damage has occurred, and it plays an important role in DNA damage checkpoint, embryonic development and tumor suppression (1). Chk1 is activated in response to replication blocks and genotoxic stress, via phosphorylation of serines 317 and 345 (2). Activated Chk1 can bind to, phosphorylate (at serine 216) and inactivate cdc25c (3,4). Phosphorylation of cdc25c prevents activation of the CDC2-cyclin B complex and prevents entry into M-phase (3, 4). |
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Western blot analysis on HeLa cell lysate using anti-Chk1, dilution 1:10,000
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-CHK1.