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Anti-CCL4 Antibody EP521Y
Also for CCL4 (NM_002984)
|A synthetic peptide corresponding to residues in the N-terminus of human MIP-1 beta/CCL4 was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|IgG fraction (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens chemokine (C-C motif) ligand 4 (CCL4)|
|ACT2; AT744.1; G-26; HC21; LAG-1; LAG1; MIP-1-beta; MIP1B; MIP1B1; SCYA2; SCYA4|
|Macrophage inflammatory protein-1 beta (MIP-1 beta/CCL4) belongs to the intercrine beta (chemokine CC) family (1). MIP-1 beta functions to promote accumulation of lymphocyte, marcorphages, monocytes, and NK cells during various inflammatory conditions through its chemotactic properties. MIP-1 beta is an essential inhibitor of cell infection by human immunodeficiency virus type 1 (HIV-1). MIP-1 beta inhibits HIV-1 by blocking or down-regulating the receptors CCR5, one of coreceptor for HIV-1 entry (2). In human, MIP-1 beta exhibits specific attractant activities to CD4+ T lymphocytes, with minor activities to T cells from naive (CD45RA) phenotype (3). |
Cytokine-cytokine receptor interaction
Toll-like receptor signaling pathway
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Western blot - Macrophage Inflammatory Protein 1 beta antibody [EP521Y]; Anti-Macrophage Inflammatory Protein 1 beta antibody [EP521Y] at 1/500000 dilution + approximately 0.05ug/lane [0.5ug/200ul] of recombinant protein was loaded on the membrane.Secondary.Goat anti-rabbit HRP labeled at 1/2000 dilution.Predicted band size : 10 kDa.Observed band size : 10 kDa.