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Anti-CCL4 Antibody EP521Y


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against CCL4 (Clone EP521Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401043) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the N-terminus of human MIP-1 beta/CCL4 was used as an immunogen.
Clone NameEP521Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000-10000
Predicted MW Explanation 10 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens chemokine (C-C motif) ligand 4 (CCL4)
Alternative NameACT2; AT744.1; G-26; HC21; LAG-1; LAG1; MIP-1-beta; MIP1B; MIP1B1; SCYA2; SCYA4
Database LinkNP_002975
Entrez Gene 6351 Human
FunctionMacrophage inflammatory protein-1 beta (MIP-1 beta/CCL4) belongs to the intercrine beta (chemokine CC) family (1). MIP-1 beta functions to promote accumulation of lymphocyte, marcorphages, monocytes, and NK cells during various inflammatory conditions through its chemotactic properties. MIP-1 beta is an essential inhibitor of cell infection by human immunodeficiency virus type 1 (HIV-1). MIP-1 beta inhibits HIV-1 by blocking or down-regulating the receptors CCR5, one of coreceptor for HIV-1 entry (2). In human, MIP-1 beta exhibits specific attractant activities to CD4+ T lymphocytes, with minor activities to T cells from naive (CD45RA) phenotype (3).
Related PathwaySecreted ProteinTransmembraneDruggable Genome Cytokine-cytokine receptor interactionChemokine signaling pathwayToll-like receptor signaling pathwayCytosolic DNA-sensing pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Macrophage Inflammatory Protein 1 beta antibody [EP521Y]; Anti-Macrophage Inflammatory Protein 1 beta antibody [EP521Y] at 1/500000 dilution + approximately 0.05ug/lane [0.5ug/200ul] of recombinant protein was loaded on the membrane.Secondary.Goat anti-rabbit HRP labeled at 1/2000 dilution.Predicted band size : 10 kDa.Observed band size : 10 kDa.


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