Home All anti-HSPD1 antibodies
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Also for HSPD1 (NM_002156)
|A synthetic peptide corresponding to residues in human Heat Shock Protein 60 was used as immunogen.|
|Human, Mouse, Rat
||WB: 1: 20,000-50,000; IHC: 1:250-500; ICC: 1:250-500; FC: 1:20; IP: 1:50
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens heat shock 60kDa protein 1 (chaperonin) (HSPD1), nuclear gene encoding mitochondrial protein, transcript variant 1|
|CPN60; GROEL; HLD4; HSP-60; HSP60; HSP65; HuCHA60; SPG13|
|The 60 kDa heat shock protein (HSP60) is a highly conserved protein that act as a chaperone involved in correct folding of newly synthesized proteins (1-2). Mainly expressed in mitochondria, HPS60 has also been found in the cytosol of normal heart and muscle cells. In normal cardiac myocytes, cytosolic HSP60 complexes with Bax, Bak and Bcl-XL (3). While over expression of HSP60 prevents apoptosis in cardiac cells; is has also been shown that HSP60 accelerated the activation of Caspase 3 during apoptosis (4-5). Therefore, the role of HSP60 in apoptosis may be both pro- and anti-apoptotic, depending on the cell type, or apoptotic stimulus.|
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Western blot analysis on T47D cell lysate using anti-anti-HSP60, dilution 1:50,000.
Immunohistochemical analysis of paraffin-embedded human breast adenocarcinoma using anti-HSP-60.