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OriGene Antibodies in recent publications
A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [anti-DDK]
Excitotoxicity Upregulates SARM1 Protein Expression and Promotes Wallerian-Like Degeneration of Retinal Ganglion Cells and Their Axons Invest. Ophthalmol. Vis. Sci., Apr 2013; 54: 2771 - 2780. [SARM1]
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX Nature 497, 122-126 doi:10.1038/nature12052 [anti-DDK]
Natriuretic Peptide Receptor-3 Gene (NPR3): Nonsynonymous Polymorphism Results in Significant Reduction in Protein Expression Because of Accelerated Degradation Circ Cardiovasc Genet, Apr 2013; 6: 201 - 210. [NPR3]
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 Home All anti-PPP1R1B antibodies

Anti-PPP1R1B Antibody EP721Y

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Specifications Related Products Conjugation/Bulk FAQs
SKU Description Amount Price Availability*  
TA300631
  • Rabbit Monoclonal Antibody against PPP1R1B (Clone EP721Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC403149) , 20ug
 100µl $325 3-7 Days Add to Shopping Cart
WB(1)
IHC(1)
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Also for PPP1R1B (NM_032192)
cDNA Clone shRNA/siRNA Lysate Protein Antibody
Gene NameHomo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 1B (PPP1R1B), transcript variant 1
Synonyms:DARPP-32; DARPP32
ImmunogenA synthetic peptide corresponding to residues near the N-term of human DARPP-32 was used as immunogen.
Buffer50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Clone NameEP721Y IsotypeIgG
Species ReactivityHuman, Rat Concentration
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:5,000-20,0000; IHC: 1:250-500; ICC: 1:50-100; IP: 1:50
BackgroundThe 32kDa dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein (DARPP-32) can either function as a serine/threonine kinase or as a serine/threonine phosphatase depending upon which particular amino acid residue is phosphorylated (1). When phosphorylated by protein kinase A (PKA) at threonine 34, DARPP-32 becomes a potent inhibitor of protein phosphatase-1 (2-3). Alternatively, when phosphorylated at threonine 75 by cyclin-dependent kinase 5(Cdk5), DARPP-32 is converted into an inhibitor of PKA (1). DARPP-32 and truncated DARPP (t-DARPP) are overexpressed in gastric cancers (4).
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis on human brain lysate using anti-DARP-32 (C-term), dilution 1:20,000.
IHC Image
Immunohistochemical analysis of paraffin-embedded human gastric adenocarcinoma using anti-DARPP-32 (C-term).

 

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