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Home Antibody All anti-PPP1R1B antibodies

Anti-PPP1R1B Antibody EP721Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300631
  • Rabbit Monoclonal Antibody against PPP1R1B (Clone EP721Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403149) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for PPP1R1B (NM_032192)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-term of human DARPP-32 was used as immunogen.
Clone NameEP721Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:5,000-20,0000; IHC: 1:250-500; ICC: 1:50-100; IP: 1:50
Predicted MW Explanation 32 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 1B (PPP1R1B), transcript variant 1
Alternative NameDARPP-32; DARPP32
Database LinkNP_115568
Entrez Gene 84152 Human
FunctionThe 32kDa dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein (DARPP-32) can either function as a serine/threonine kinase or as a serine/threonine phosphatase depending upon which particular amino acid residue is phosphorylated (1). When phosphorylated by protein kinase A (PKA) at threonine 34, DARPP-32 becomes a potent inhibitor of protein phosphatase-1 (2-3). Alternatively, when phosphorylated at threonine 75 by cyclin-dependent kinase 5(Cdk5), DARPP-32 is converted into an inhibitor of PKA (1). DARPP-32 and truncated DARPP (t-DARPP) are overexpressed in gastric cancers (4).
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - DARPP32 antibody [EP721Y]; Anti-DARPP32 antibody [EP721Y] at 1/20000 dilution + Human brain lysate at 10 ug.Predicted band size : 32 kDa.Observed band size : 32 kDa.
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - DARPP32 antibody [EP721Y]; Immunohistochemical analysis human gastric adenocarcinoma using TA300631.

 

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