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Anti-CDK5 Antibody EP715Y
Also for CDK5 (NM_004935)
|A synthetic peptide corresponding to residues in the C-terminus of human Cdk5 was used as immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:2000 - 1:10000; IHC-P: Use at an assay dependent dilution; ICC: 1:100 - 1:250; FC: 1:30; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Homo sapiens cyclin-dependent kinase 5 (CDK5), transcript variant 1|
Entrez Gene 1020 Human
Entrez Gene 12568 Mouse
Entrez Gene 140908 Rat
|Cyclin-dependent protein kinase 5 (Cdk5) is a unique member of the family of cyclin-dependent kinases that is not directly involved in the progression of proliferating cells through the cell cycle (1). Distributed in most tissues and various cell lines, Cdk5 is active primarily in neuronal tissues, because of its association with neuron-specific activators such as p35 (a neural-specific regulatory subunit of Cdk5) (2). In addition to its role in muscle and neuronal differentiation, Cdk5 also contributes to the assembly, organization and stability of the axonal cytoskeleton in neurons, promotes neurite outgrowth and axon guidance in developing neurons, participates in the regulation of synaptic transmission and provides an additional pathway to cellular apoptosis (3-5). Cdk5 phosphorylates MAP1b, Tau, neurofilament proteins, caldesmon and proteins of the synaptic vesicles. Deregulation of Cdk5 has profound cytotoxic effects and is implicated in the development of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis (6). |
|Protein KinaseDruggable Genome Axon guidanceAlzheimer's disease|
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Western blot - Anti-Cdk5 antibody [EP715Y]; .developed using the ECL technique.Performed under reducing conditions.Predicted band size : 33 kDa.Additional bands at : 52 kDa (possible non-specific binding).
Western blot - Cdk5 antibody [EP715Y]; Anti-Cdk5 antibody [EP715Y] at 1/10000 dilution + HeLa cell lysate.Predicted band size : 33 kDa.Observed band size : 33 kDa.
Immunohistochemistry (Paraffin-embedded sections) - Cdk5 antibody [EP715Y]; Paraffin-embedded human brain stained for Cdk5 with TA300618 at 1/100 dilution