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Home Antibody All anti-PTPRC antibodies

Anti-PTPRC Antibody EP322Y

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA300611
  • Rabbit Monoclonal Antibody against PTPRC (Clone EP322Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401003) , 20ug Explanation
100ul $325 3-7 Days

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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IHC(4)
FC(1)
Assay(1)
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Also for PTPRC (NM_002838)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the C-terminal domain of human CD45 was used as immunogen.
Clone NameEP322Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *ASSAY, IHC, FC Suggested DilutionsWB: 1:5000 - 1:10000; FC: 1:15; IHC-P: 1:100 - 1:250
Predicted MW Explanation 180 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1
Alternative NameB220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200
Database LinkNP_002829
Entrez Gene 5788 Human
FunctionCD45, also known as the leukocyte common antigen (LCA), is a transmembrane protein-tyrosine phosphatase (PTPase) that is expressed in hematopoietic cells except ethrocytes and platelets (1). CD 45 has been implicated in activating, differentiating and the development of the immune system. It regulates T-or B-cell activation during receptor-specific recognition by dephosphorylating tyrosine residues in protein kinase substrates. It is also required for T- and B-cell activation by regulating Lck & Fyn and Lyn & Blk respectively (2). Additionally, the expression of the CD45 5 isoforms can be seen in the various stages of differentiation of normal hematopoietic cells depending on the activation status of the cell (3).
Related PathwayES Cell Differentiation/IPSTransmembranePhosphataseDruggable Genome Cell adhesion molecules (CAMs)T cell receptor signaling pathwayFc gamma R-mediated phagocytosisPrimary immunodeficiency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Other - Anti-CD45 antibody [EP322Y]; Equilibrium disassociation constant (KD).
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD45 antibody [EP322Y]; TA300611 showing positive staining in Normal spleen tissue.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD45 antibody [EP322Y]; TA300611 showing positive staining in Normal colon lymphoid cells tissue.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD45 antibody [EP322Y]; TA300611 showing negative staining in Skeletal muscle tissue.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD45 antibody [EP322Y]; TA300611 showing negative staining in Normal kidney tissue.
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Flow Cytometry / FACS - CD45 antibody [EP322Y]; TA300611, used at a 1/15 dilution, detecting CD45 on Jurkat cells (red).
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