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Anti-PIK3CA Antibody EP383Y
Also for PIK3CA (NM_006218)
|A synthetic peptide of human near the C-term of PI3-K p110 alpha was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; ICC/IF: 1:100 - 1:250; IP: 1:30
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt or IHC.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or IHC.
|Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA)|
|CLOVE; CWS5; MCAP; MCM; MCMTC; p110-alpha; PI3K|
|PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. PI3-K consists of two subunits; p85 and p10. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K (1-2). Four isoforms of p110 has been found; ?, ?, ?, and the ? subunit. The alpha isoform, also known as PI3KCA, is a transforming oncogene (3) that was shown to have activating mutations in nine types of cancers such as colon, brain, breast and stomach (4-5). Three hot spot mutations (E542K and E545K; and H1047R) make p110? a potential drug target. |
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
Signaling by GPCR
Toll-like receptor signaling pathway
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Western blot - PI 3 Kinase catalytic subunit alpha antibody [EP383Y]; Anti-PI 3 Kinase catalytic subunit alpha antibody [EP383Y] at 1/5000 dilution + Jurkat cell lysate at 10 µg.Predicted band size : 110 kDa.Observed band size : 110 kDa.
Immunocytochemistry/ Immunofluorescence - PI 3 Kinase catalytic subunit alpha antibody [EP383Y]; ab40776 staining HeLa cells (1:100 dilution).