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Anti-PARK2 Antibody EP668Y

WB(1)

IHC(1)

IF(1)

Gene Name Homo sapiens parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2), transcript variant 3 Synonyms: AR-JP; LPRS2; PDJ; PRKN Immunogen A synthetic peptide corresponding to residues in human Parkin was used as immunogen. Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Clone Name EP668Y Isotype IgG Species Reactivity Human, Mouse, Rat Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB, IHC, IF Suggested Dilutions WB: 1:500; IHC: 1:50-100; ICC: 1: 100-250; FC: 1:80 Background Parkin is a RING-type E3 ubiquitin-protein ligase which binds to E2 ubiquitin-conjugating enzymes. Parkin is composed of a ubiquitin-like domain at its amino terminus and two RING finger motifs flanking a cysteine-rich region that is known as the in between RING fingers (IBR) motif (1-2). Involved in the ubiquitination pathway for misfolded proteins derived from endoplasmic reticulum, Parkin contributes to protection from neurotoxicity induced by unfolded protein stresses. Parkin can also ubiquitinates itself to promotes its own degradation (3).Defective Parkin is involved in Parkinson’s diseases and in autosomal recessive juvenile Parkinsonism (AR-JP) (4-5) Related Pathway

Related Lysate from OriGene • Transient overexpression lysate of Parkinson disease (autosomal recessive, juvenile) 2, parkin (PARK2), transcript variant 3 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • PARK2 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • PARK2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Park2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • PARK2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Park2 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2), transcript variant 3 as transfection-ready DNA • Lenti ORF clone of Human parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2), transcript variant 3 , Myc-DDK-tagged • Lenti ORF clone of Human parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2), transcript variant 3, mGFP tagged • GFP-tagged ORF clone of Homo sapiens parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2), transcript variant 3 as transfection-ready DNA • Myc-DDK-tagged ORF clone of Homo sapiens parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2), transcript variant 3 as 200 ug transfection-ready DNA Related cDNA Clones • Homo sapiens parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2), transcript variant 3 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)