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Anti-TRAF6 Antibody EP591Y


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against TRAF6 (Clone EP591Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403440) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the C-term of human TRAF6 was used as immunogen.
Clone NameEP591Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, FC Suggested DilutionsWB: 1:2000 - 1:10000; FC: 1:50; IHC-P: Use at an assay dependent concentration
Predicted MW Explanation 58 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens TNF receptor-associated factor 6, E3 ubiquitin protein ligase (TRAF6), transcript variant 1
Alternative NameMGC:3310; RNF85
Database LinkNP_665802
Entrez Gene 7189 Human
Entrez Gene 22034 Mouse
Entrez Gene 311245 Rat
FunctionTumour-necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is the only TRAF family member that participates in signal transduction of both the TNF receptor superfamily and the interleukin-1 receptor /Toll-like receptor superfamily. Acting as an adapter protein and a signal transducer, TRAF6 links members of the TNF receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. (1-2). TRAF6 stimulates NFkB through interaction with CD40, TNFR, IL-1R, p75 NTR, and TRANCE receptor. Additionally, o verexpression of TRAF6 is sufficient to activate signaling pathways leading to NF-B and AP-1 in the absence of extracellular stimuli (3-5).
Related PathwayDruggable Genome MAPK signaling pathwayUbiquitin mediated proteolysisEndocytosisToll-like receptor signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - TRAF6 antibody [EP591Y]; Anti-TRAF6 antibody [EP591Y] at 1/10000 dilution + Jurkat cell lysate.Predicted band size : 58 kDa.
Immunohistochemistry (Paraffin-embedded sections) - TRAF6 antibody [EP591Y]; Immunohistochemical analysis of paraffin-embedded human colon adenocarcinoma using anti-TRAF6
Flow Cytometry - TRAF6 antibody [EP591Y]; TA300582 staining TRAF6 in Human platelet cells by Flow cytometry.Cells were fixed in paraformaldehyde and permeabilized using 0.1% Triton-X-100 in 2% BSA for 15 minutes. Primary antibody used at a 1/200 dilution and incubated for 16 hours at 4°C. The secondary antibody used was an Alexa Fluor488 conjugated chicken anti-rabbit IgG (H+L) at a 1/500 dilution. P : Permeabilized .US : Unstained (Red Peak) IGG RB : IgG Rabbit (Blue Peak) .TRAF6 Ab (Green Peak)


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