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Anti-IL15 Antibody EP433Y


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against IL15 (Clone EP433Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403532) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA recombinant human IL-15 was used an immunogen.
Clone NameEP433Y IsotypeIgG
Species ReactivityRecombinant Fragment ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:5000
Predicted MW Explanation 18 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens interleukin 15 (IL15), transcript variant 1
Alternative NameIL-15; MGC9721; MGC9721; OTTHUMP00000164617; Interleukin 15
Database LinkNP_751914
FunctionInterleukin 15 (IL-15) is a cytokine that shares many biological activities with IL-2. Both cytokines interact with the ß and ? component of the IL-2 receptor. However, unlike IL-2 which is secreted only by T cells, IL-15 is expressed preferentially by nonlymphoid tissues, epithelial, and fibroblast cell lines (1). Two isoforms of human IL-15 are known. The longer form is localized to the plasma membrane or may be secreted, while the other (the shorter form) is found within the cytoplasm and the nucleus (2). IL-15 regulates T and natural killer cell activation and proliferation, causes B cell proliferation and differentiation and stimulates chemotaxis of T cells (3-4). It also induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. High concentrations of IL-15 have been observed in inflamed joints of rheumatoid arthritis patients, suggesting a role for IL-15 in inflammatory diseases where there is recruitment of leukocytes (5).
Related PathwaySecreted ProteinDruggable Genome Cytokine-cytokine receptor interactionJak-STAT signaling pathway

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WB Image
Western blot - IL15 antibody [EP433Y]; Anti-IL15 antibody [EP433Y] at 1/5000 dilution + recombinant IL15 protein at 0.05ug/lane.Predicted band size : 18 kDa.Observed band size : 31 kDa .


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