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 Home All anti-CCNE1 antibodies

Anti-CCNE1 Antibody EP435E

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SKU Description Amount Price Availability*  
TA300577
  • Rabbit Monoclonal Antibody against CCNE1 (Clone EP435E)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400495) , 20ug
 100µl $325 3-7 Days
TA802519S
  • Purified GAPDH mouse monoclonal antibody (Loading control), clone 2D9
 30ul
$100
$50*		 In Stock
Add to Shopping Cart
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
WB(1)
IF(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Cyclin E1 was used as immunogen. This antibody is predicted to detect the splice isoform 2 based on sequence analysis.
Clone NameEP435E IsotypeIgG
Species ReactivityHuman Concentration
Guaranteed Application *WB, IF Suggested DilutionsWB: 1: 1,000-2,000; IHC: 1: 100-250; FC: 1:20; IP: 1:80
Buffer50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Reference Data

Target NameHomo sapiens cyclin E1 (CCNE1)
Alternative NameCCNE
Database LinkNP_001229
FunctionCyclin E1 is a member of the cyclin E family that can associate with and activate cyclin-dependent kinase Cdk2. Expression of cyclin E1 is essential for the control of the cell cycle at the late G1 and early S phase (1). The cyclin E/Cdk2 complex plays an essential and limiting role in the transition between G1 and S phase as well as the initiation of DNA replication (2) Ubiquination by the Cul-3 pathway and by Fbw7 regulates cyclin E1 levels and is critically important in normal cells. Abnormally high levels of cyclin E expression have frequently been observed in human cancers (3). Moreover, high cyclin E1 levels correlate with increased tumor aggression and poor prognosis (4).
Related Pathway
Cell cycle
TGF Beta Signaling Pathway

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WB Image
Western blot analysis on Hela cell lysate using anti-Cyclin E1, dilution 1:2,000.
IF Image
Immunofluorescent staining of HeLa cells using anti-Cyclin E1.

 

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