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Anti-CCNE1 Antibody EP435E
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Also for CCNE1 (NM_001238)
|A synthetic peptide corresponding to residues in human Cyclin E1 was used as immunogen. This antibody is predicted to detect the splice isoform 2 based on sequence analysis.|
||WB: 1: 1,000-2,000; IHC: 1: 100-250; FC: 1:20; IP: 1:80
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens cyclin E1 (CCNE1)|
|Cyclin E1 is a member of the cyclin E family that can associate with and activate cyclin-dependent kinase Cdk2. Expression of cyclin E1 is essential for the control of the cell cycle at the late G1 and early S phase (1). The cyclin E/Cdk2 complex plays an essential and limiting role in the transition between G1 and S phase as well as the initiation of DNA replication (2) Ubiquination by the Cul-3 pathway and by Fbw7 regulates cyclin E1 levels and is critically important in normal cells. Abnormally high levels of cyclin E expression have frequently been observed in human cancers (3). Moreover, high cyclin E1 levels correlate with increased tumor aggression and poor prognosis (4). |
TGF Beta Signaling Pathway
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Western blot analysis on Hela cell lysate using anti-Cyclin E1, dilution 1:2,000.
Immunofluorescent staining of HeLa cells using anti-Cyclin E1.