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Home Antibody All anti-SMAD2 antibodies

Anti-SMAD2 Antibody EP567Y


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA300564 Rabbit Monoclonal Antibody against SMAD2 (Clone EP567Y) 100ul $325 3-7 Days
LC401783 SMAD2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for SMAD2 (NM_005901)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the MH2 domain of human Smad2 was used as immunogen.
Clone NameEP567Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application * Suggested DilutionsWB: 1:1000; IHC-P: Use at an assay dependent dilution; ICC: 1:250 - 1:500; FC: 1:20 - 1:100
Predicted MW Explanation 58 kDa
BufferpH: 7.20Preservative: 0.01% Sodium azideConstituents: 59% PBS, 40% Glycerol, 0.05% BSA
Purification Protein A purified
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens SMAD family member 2 (SMAD2), transcript variant 1
Alternative NamehMAD-2; hSMAD2; JV18; JV18-1; MADH2; MADR2
Database LinkNP_005892
Entrez Gene 4087 Human
Entrez Gene 17126 Mouse
Entrez Gene 29357 Rat
FunctionSmad 2 is a member of the Mothers Against Dpp (MAD)-related family of proteins. So far, eight Smads have been identified and can be divided in 3 subgroups based on their structure and functions; pathway-restricted, common mediator and inhibitory Smad. Smad 2 and 3 serve as pathway-restricted Smads for the TGF-beta/activin signaling pathways (1-2). Smad 2 is phosphorylated by the TGF-beta type 1 receptor kinase on Ser 465 and Ser 467. Phosphorylation of both serines is essential for Smad 2-Smad4 heteromeric complex and dissociation of Smad 2 from the TGF-beta type 1 receptor (3). Once phosphorylated Smad2 translocate to the nucleus where it associates with DNA-binding proteins and forming a transcriptional complex (4). Unlike Smad 3 and 4, Smad 2 does not directly bind DNA (5).
Related PathwayStem cell relevant signaling - JAK/STAT signaling pathwayStem cell relevant signaling - TGFb/BMP signaling pathwayES Cell Differentiation/IPSCancer stem cellsEmbryonic stem cellsTranscription FactorsDruggable Genome Cell cycleWnt signaling pathwayTGF-beta signaling pathwayAdherens junctionPathways in cancerColorectal cancerMore Pathways >>

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* OriGene provides validated application data and protocol, with money back guarantee.


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