Anti-MAP2K6 Antibody, EP557Y

Also for MAP2K6 (NM_002758)

Gene Name	Homo sapiens mitogen-activated protein kinase kinase 6 (MAP2K6)
Synonyms:	MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3; SAPKK3
Immunogen	A synthetic peptide corresponding to residues in the N-term of human MKK6 was used as immunogen.
Buffer	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Clone Name	EP557Y	Isotype	IgG
Species Reactivity	Human, Mouse, Rat	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:2000-10,000; IP: 1:50
Background	Mitogen-acitvated protein kinase kinase 6 (MKK6) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MAPKs require dual phosphorylation on threonine and tyrosine residues, an activation step carried out by MAPK kinase (1-2). MKK6, closely related to MKK3, efficiently phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines and environmental stress but not JNK or ERK (3). MTK1 phosphorylates MKK6 on serine 207 and threonine 211 (4).
Related Pathway	Focal Adhesion MAPK signaling pathway TGF Beta Signaling Pathway Toll-like receptor signaling pathway

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WB Image

Western blot analysis on Hela cell lysate using anti-MKK6, dilution 1:10,000.

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Anti-MAP2K6 Antibody EP557Y

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