OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-ARHGAP5 antibodies

Anti-ARHGAP5 Antibody EP489Y

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300551
  • Rabbit Monoclonal Antibody against ARHGAP5 (Clone EP489Y)
100ul 325 In Stock
Add to Shopping Cart
WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human p190-B RhoGAP was used as immunogen.
Clone NameEP489Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500; IHC-P: Use at an assay dependent concentration; FC: 1:60
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Protein A purified
Note Is unsuitable for ICC or IP.

Reference Data

Target NameHomo sapiens Rho GTPase activating protein 5 (ARHGAP5), transcript variant 2
Alternative NameGFI2; p190-B; p190BRhoGAP; RhoGAP5
Database LinkNP_001164
Entrez Gene 394 Human
Entrez Gene 11855 Mouse
Entrez Gene 299012 Rat
FunctionThe p190 Rho GTPase activating protein RhoGAP) family includes two closely related proteins, p190-A and p190-B. p190-B contains an N-terminal GTPase domain and a C-terminal Rho-GAP domain (1). p190-B can be directly phosphorylated on a single identified tyrosine residue by the activated insulin and IGF-1 receptors. This phosphorylation causes p190-B to translocate to the lipid rafts of the plasma membrane, where it can facilitate the inactivation of the Rho GTPase. P190-B also has been shown to be tyrosine phosphorylated by c-Src and v-Src. Additionall; the GAP domain of p190-B as shown to attenuate signal-transducing activity of Rac, Rho and CDC42 (2-3).
Related Pathway
Focal Adhesion

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - RhoGAP antibody [EP489Y]; All lanes : Anti-RhoGAP antibody [EP489Y] at 1/500 dilution.Lane 1 : Hela cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : MCF-7 cell lysate.Lane 4 : K562 cell lysate.Lane 5 : A431 cell lysate.Lane 6 : 293 cell lysate.Lane 7 : NIH 3T3 cell lysate.Lane 8 : PC12 cell lysate.Predicted band size : 171 kDa.Observed band size : 190 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - RhoGAP antibody [EP489Y]; TA300551, at a 1/100 dilution, staining human RhoGAP in stomach carcinoma by Immunohistochemistry, Paraffin embedded tissue

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title