Homo sapiens GRB2-associated binding protein 1 (GAB1), transcript variant 2
Synonyms:
GRB2-associated binding protein 1
Immunogen
A synthetic peptide corresponding to residues in human Gab1 was used as immunogen. The antibody is predicted to detect splice isoform 2 based on sequence analysis.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Gab1 (Grb2-associated binder-1) is an adaptor protein that serves to activate numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs). Gab1 is a substrate of various RTKs, including EGFR, insulin receptor, cytokine receptors, and B cell antigen receptors; and it acts as a docking protein for several SH2-containing proteins (1-3). Tyrosine-phosphorylated Gab1 may recruit cytosolic signaling proteins to the cellular membrane, where they can act on membrane-bound targets as well as activate downstream pathways (4)
Related Pathway
EGFR1 Signaling Pathway
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