Home All anti-PTPN6 antibodies
Anti-PTPN6 Antibody Y476
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for PTPN6 (NM_002831)
|A synthetic peptide corresponding to residues in the C-term of human DHP-1 was used as immunogen. This antibody is predicted to detect isoforms 2 and 3 based on sequence analysis.|
|Human, Mouse, Rat
||WB: 1: 1000; IHC: 1:50-100; FC: 1:20; IP: 1:50
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens protein tyrosine phosphatase, non-receptor type 6 (PTPN6), transcript variant 1|
|HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1|
|SHP-1 (also called PTP1C, SH-PP1, HCP, SHP and PTPN6) is a protein tyrosine phosphatase (PTP) predominantly expressed in hematopoietic cells, and regulates multiple signaling pathways involved in hematopoietic cell growth, differentiation and activation (1). After cell stimulation, SHP-1 (as well as SHP-2), translocate from cytosol to plasma membrane and bind to the tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). SHP-1 has been involved in the negative regulation of various growth promoting receptors including receptor tyrosine kinase (c-Kit, CSF-1, EGF), cytokine receptors (IL-3, IFN-a/b) and other tyrosine based receptor CD22, B & T cell Ag receptor, Lck, Zap-70 and Vav (3-5). |
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Western blot analysis of anti-SHP-1 (C-term) 1:1,000 dilution A- A431 B- Jurkat C- K562
Immunohistochemical analysis of paraffin-embedded human lymph node using anti-SHP-1 (C-term).