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Anti-BLNK Antibody Y491
Also for BLNK (NM_013314)
|A synthetic peptide corresponding to residues near the C-term of human BLNK was used as immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:500; IHC-P: Use at an assay dependent dilution; IP: 1:20
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt.
|Homo sapiens B-cell linker (BLNK), transcript variant 1|
|AGM4; BASH; bca; BLNK-S; LY57; SLP-65; SLP65|
Entrez Gene 29760 Human
Entrez Gene 17060 Mouse
Entrez Gene 499356 Rat
|B-cell linker protein (BLNK, also known as SLP65, BASH, and BCA) is a B cell adaptor that plays an important role in B cell development and in BCR-signal transduction. Since BLNK does not encode any intrinsic enzymatic activity, its function is to serve as a scaffold for assembling macromolecular complexes which includes enzymes (PLC gamma, Vav and Btk) and additional linker proteins (Grb2 and Nck) (1-3) . In addition, BLNK binds Btk and is required for activation of the transcription factor NF-?B. Tyrosine phosphorylation of BLNK by Syk provides specific docking sites for these SH2-containing effector proteins which in turn permits phosphorylation and/or activation of their respective signaling pathways. |
|Druggable Genome B cell receptor signaling pathwayPrimary immunodeficiency|
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Western blot - BLNK antibody [Y491]; Anti-BLNK antibody [Y491] at 1/500 dilution + Raji cell lysate.Observed band size : 68 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - BLNK antibody [Y491]; TA300524 at a 1:50 dilution staining BLNK in human spleen tissue using Immunohistochemistry, Paraffin Embedded Tissue.