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Home Antibody All anti-BLNK antibodies

Anti-BLNK Antibody Y491

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300524
  • Rabbit Monoclonal Antibody against BLNK (Clone Y491)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402244) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-term of human BLNK was used as immunogen.
Clone NameY491 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500; IHC-P: Use at an assay dependent dilution; IP: 1:20
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens B-cell linker (BLNK), transcript variant 1
Alternative NameAGM4; BASH; bca; BLNK-S; LY57; SLP-65; SLP65
Database LinkNP_037446
Entrez Gene 29760 Human
Entrez Gene 17060 Mouse
Entrez Gene 499356 Rat
FunctionB-cell linker protein (BLNK, also known as SLP65, BASH, and BCA) is a B cell adaptor that plays an important role in B cell development and in BCR-signal transduction. Since BLNK does not encode any intrinsic enzymatic activity, its function is to serve as a scaffold for assembling macromolecular complexes which includes enzymes (PLC gamma, Vav and Btk) and additional linker proteins (Grb2 and Nck) (1-3) . In addition, BLNK binds Btk and is required for activation of the transcription factor NF-?B. Tyrosine phosphorylation of BLNK by Syk provides specific docking sites for these SH2-containing effector proteins which in turn permits phosphorylation and/or activation of their respective signaling pathways.
Related PathwayDruggable Genome B cell receptor signaling pathwayPrimary immunodeficiency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - BLNK antibody [Y491]; Anti-BLNK antibody [Y491] at 1/500 dilution + Raji cell lysate.Observed band size : 68 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - BLNK antibody [Y491]; TA300524 at a 1:50 dilution staining BLNK in human spleen tissue using Immunohistochemistry, Paraffin Embedded Tissue.

 

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