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Anti-BMX Antibody Y396
|A synthetic peptide corresponding to residues in the pleckstrin homology domain of human ETK/BMX was used as immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:2000; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt or ICC.
|Homo sapiens BMX non-receptor tyrosine kinase (BMX), transcript variant 2|
|ETK; PSCTK2; PSCTK3|
Entrez Gene 660 Human
Entrez Gene 12169 Mouse
Entrez Gene 367786 Rat
|Etk (epithelial and endothelial tyrosine kinase) is a member of the TEC family of non-receptor protein tyrosine kinase which includes Btk, Itk and TEC. Etk is composed of a pleckstrin domain, an SH3 and SH2 domain and a catalytic kinase domain (1). Etk is implicated in cell adhesion, migration, proliferation, survival as well as signal transduction (2). In PCA, Etk activation by IL-6 is mediated by PI3-K (3). It as also been shown in TNF-induced angiogenesis, TNF activates Etk through TNFR2 (4). Additionally, in the AR pathway, ETtk, FAK and Src form a complex. FAK activates Src which in turn activates Etk by phosphorylating Etk tyrosine residue 566 (5).|
|Protein KinaseDruggable Genome |
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Western blot - BMX antibody [Y396]; Anti-BMX antibody [Y396] at 1/500 dilution + HeLa cell lysate.Predicted band size : 78 kDa.Observed band size : 75 kDa .