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Home Antibody All anti-PTPRC antibodies

Anti-PTPRC Antibody Y321

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300505
  • Rabbit Monoclonal Antibody against PTPRC (Clone Y321)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401003) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for PTPRC (NM_002838)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the leukocyte common antigen domain of human CD45 was used as immunogen.
Clone NameY321 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:5,000-10,000; IP: 1:50
Predicted MW Explanation 147 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Protein A purified
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1
Alternative NameB220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200
Database LinkNP_002829
Entrez Gene 5788 Human
FunctionCD45, also known as the leukocyte common antigen (LCA), is a transmembrane protein-tyrosine phosphatase (PTPase) that is expressed in hematopoietic cells except ethrocytes and platelets (1). CD 45 has been implicated in activating, differentiating and the development of the immune system. It regulates T-or B-cell activation during receptor-specific recognition by dephosphorylating tyrosine residues in protein kinase substrates. It is also required for T- and B-cell activation by regulating Lck & Fyn and Lyn & Blk respectively (2). Additionally, the expression of the CD45 5 isoforms can be seen in the various stages of differentiation of normal hematopoietic cells depending on the activation status of the cell (3).
Related PathwayES Cell Differentiation/IPSTransmembranePhosphataseDruggable Genome Cell adhesion molecules (CAMs)T cell receptor signaling pathwayFc gamma R-mediated phagocytosisPrimary immunodeficiency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - CD45 antibody [Y321]; Anti-CD45 antibody [Y321] at 1/5000 dilution + Jurkat cell lysate.Predicted band size : 147 kDa.Observed band size : 180 kDa .

 

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