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Anti-PTPRC Antibody Y321
Also for PTPRC (NM_002838)
|A synthetic peptide corresponding to residues in the leukocyte common antigen domain of human CD45 was used as immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:5,000-10,000; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Protein A purified (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1|
|B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200|
|CD45, also known as the leukocyte common antigen (LCA), is a transmembrane protein-tyrosine phosphatase (PTPase) that is expressed in hematopoietic cells except ethrocytes and platelets (1). CD 45 has been implicated in activating, differentiating and the development of the immune system. It regulates T-or B-cell activation during receptor-specific recognition by dephosphorylating tyrosine residues in protein kinase substrates. It is also required for T- and B-cell activation by regulating Lck & Fyn and Lyn & Blk respectively (2). Additionally, the expression of the CD45 5 isoforms can be seen in the various stages of differentiation of normal hematopoietic cells depending on the activation status of the cell (3). |
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Western blot - CD45 antibody [Y321]; Anti-CD45 antibody [Y321] at 1/5000 dilution + Jurkat cell lysate.Predicted band size : 147 kDa.Observed band size : 180 kDa .